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Aortic Distensibility and Extent and Complexity of Coronary Artery Disease in Patients with Stable Hypertensive and Nonhypertensive Coronary Artery Disease
OBJECTIVE: To assess the relationship between aortic distensibility (AD) and the extent and complexity of atherosclerotic lesions assessed with SYNTAX score (SS) in patients with stable coronary artery disease. SUBJECTS AND METHODS: Three hundred and seventy-six consecutive patients (230 males and 1...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586749/ https://www.ncbi.nlm.nih.gov/pubmed/23327860 http://dx.doi.org/10.1159/000345842 |
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author | Elbasan, Zafer Şahin, DurmuşYıldıray Gür, Mustafa Gözübüyük, Gökhan Akıllı, Rabia Eker Koyunsever, Nermin Yıldız Türkoğlu, Caner Kıvrak, Ali Yıldırım, Arafat Çaylı, Murat |
author_facet | Elbasan, Zafer Şahin, DurmuşYıldıray Gür, Mustafa Gözübüyük, Gökhan Akıllı, Rabia Eker Koyunsever, Nermin Yıldız Türkoğlu, Caner Kıvrak, Ali Yıldırım, Arafat Çaylı, Murat |
author_sort | Elbasan, Zafer |
collection | PubMed |
description | OBJECTIVE: To assess the relationship between aortic distensibility (AD) and the extent and complexity of atherosclerotic lesions assessed with SYNTAX score (SS) in patients with stable coronary artery disease. SUBJECTS AND METHODS: Three hundred and seventy-six consecutive patients (230 males and 146 females; mean age: 61.6 ± 9.9 years) with angiographically proven coronary artery disease were included in the study. The SS was calculated using the SS algorithm on the baseline diagnostic angiogram in the 376 patients. AD was calculated from the echocardiographically derived ascending aorta diameters and hemodynamic pressure measurements in all patients. Frequencies of risk factors, biochemical and hematological data were recorded. The patients were divided into two groups according to the median AD value as AD(low) and AD(high) groups. RESULTS: The SS was higher in the AD(low) group compared with the AD(high) group (18.5 ± 10.2 vs. 8.3 ± 5.9, p < 0.001). The AD was independently related to age (β = −0.104, p = 0.019), hypertension (β = −0.202, p < 0.001) and SS (β = −0.457, p < 0.001) and was more strongly associated with SS in hypertensive patients compared to nonhypertensive patients (r = −0.524 vs. r = −0.414, p < 0.001 for all). CONCLUSION: The findings showed that impaired AD might be an independent predictor for the severity of coronary atherosclerosis, particularly in patients with hypertension. |
format | Online Article Text |
id | pubmed-5586749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-55867492017-11-01 Aortic Distensibility and Extent and Complexity of Coronary Artery Disease in Patients with Stable Hypertensive and Nonhypertensive Coronary Artery Disease Elbasan, Zafer Şahin, DurmuşYıldıray Gür, Mustafa Gözübüyük, Gökhan Akıllı, Rabia Eker Koyunsever, Nermin Yıldız Türkoğlu, Caner Kıvrak, Ali Yıldırım, Arafat Çaylı, Murat Med Princ Pract Original Paper OBJECTIVE: To assess the relationship between aortic distensibility (AD) and the extent and complexity of atherosclerotic lesions assessed with SYNTAX score (SS) in patients with stable coronary artery disease. SUBJECTS AND METHODS: Three hundred and seventy-six consecutive patients (230 males and 146 females; mean age: 61.6 ± 9.9 years) with angiographically proven coronary artery disease were included in the study. The SS was calculated using the SS algorithm on the baseline diagnostic angiogram in the 376 patients. AD was calculated from the echocardiographically derived ascending aorta diameters and hemodynamic pressure measurements in all patients. Frequencies of risk factors, biochemical and hematological data were recorded. The patients were divided into two groups according to the median AD value as AD(low) and AD(high) groups. RESULTS: The SS was higher in the AD(low) group compared with the AD(high) group (18.5 ± 10.2 vs. 8.3 ± 5.9, p < 0.001). The AD was independently related to age (β = −0.104, p = 0.019), hypertension (β = −0.202, p < 0.001) and SS (β = −0.457, p < 0.001) and was more strongly associated with SS in hypertensive patients compared to nonhypertensive patients (r = −0.524 vs. r = −0.414, p < 0.001 for all). CONCLUSION: The findings showed that impaired AD might be an independent predictor for the severity of coronary atherosclerosis, particularly in patients with hypertension. S. Karger AG 2013-03 2013-01-15 /pmc/articles/PMC5586749/ /pubmed/23327860 http://dx.doi.org/10.1159/000345842 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only. |
spellingShingle | Original Paper Elbasan, Zafer Şahin, DurmuşYıldıray Gür, Mustafa Gözübüyük, Gökhan Akıllı, Rabia Eker Koyunsever, Nermin Yıldız Türkoğlu, Caner Kıvrak, Ali Yıldırım, Arafat Çaylı, Murat Aortic Distensibility and Extent and Complexity of Coronary Artery Disease in Patients with Stable Hypertensive and Nonhypertensive Coronary Artery Disease |
title | Aortic Distensibility and Extent and Complexity of Coronary Artery Disease in Patients with Stable Hypertensive and Nonhypertensive Coronary Artery Disease |
title_full | Aortic Distensibility and Extent and Complexity of Coronary Artery Disease in Patients with Stable Hypertensive and Nonhypertensive Coronary Artery Disease |
title_fullStr | Aortic Distensibility and Extent and Complexity of Coronary Artery Disease in Patients with Stable Hypertensive and Nonhypertensive Coronary Artery Disease |
title_full_unstemmed | Aortic Distensibility and Extent and Complexity of Coronary Artery Disease in Patients with Stable Hypertensive and Nonhypertensive Coronary Artery Disease |
title_short | Aortic Distensibility and Extent and Complexity of Coronary Artery Disease in Patients with Stable Hypertensive and Nonhypertensive Coronary Artery Disease |
title_sort | aortic distensibility and extent and complexity of coronary artery disease in patients with stable hypertensive and nonhypertensive coronary artery disease |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586749/ https://www.ncbi.nlm.nih.gov/pubmed/23327860 http://dx.doi.org/10.1159/000345842 |
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