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The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress

OBJECTIVE: This study was designed to compare the oxidative stress parameters of patients with polycythemia vera (PV) to those of healthy volunteers and to investigate the probable relationship between vascular events and parameters of oxidative status such as total oxidative status (TOS), total ant...

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Autores principales: Durmus, Ahmet, Mentese, Ahmet, Yilmaz, Mustafa, Sumer, Aysegul, Akalin, Ibrahim, Topal, Cevat, Alver, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586875/
https://www.ncbi.nlm.nih.gov/pubmed/24642873
http://dx.doi.org/10.1159/000360102
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author Durmus, Ahmet
Mentese, Ahmet
Yilmaz, Mustafa
Sumer, Aysegul
Akalin, Ibrahim
Topal, Cevat
Alver, Ahmet
author_facet Durmus, Ahmet
Mentese, Ahmet
Yilmaz, Mustafa
Sumer, Aysegul
Akalin, Ibrahim
Topal, Cevat
Alver, Ahmet
author_sort Durmus, Ahmet
collection PubMed
description OBJECTIVE: This study was designed to compare the oxidative stress parameters of patients with polycythemia vera (PV) to those of healthy volunteers and to investigate the probable relationship between vascular events and parameters of oxidative status such as total oxidative status (TOS), total antioxidant status, oxidative stress index (OSI) and malondialdehyde (MDA) in PV patients. MATERIAL AND METHODS: Thirty-five PV patients (20 males and 15 females) and 20 healthy volunteers (11 males and 9 females) were enrolled. The oxidative status parameters of the patients were measured by spectrophotometric analyses at the time of diagnosis and at 6 months after treatment which consisted of phlebotomy and 100 mg/day acetyl salicylic acid with or without hydroxyurea for the high- and low-risk disease group, respectively. These parameters were compared both to healthy controls and to each other, in order to obtain the values before and after treatment. In addition, during diagnosis, the oxidative status parameters of patients with PV and a history of a vascular event were compared with those of patients with no history of a vascular event. RESULTS: The TOS, OSI and MDA values were significantly higher in the patients than in the control group at the time of diagnosis. At 6 months after phlebotomy and 100 mg/day acetyl salicylic acid therapy, the TOS, OSI and MDA values were significantly lower in the patients when compared to the pretreatment values. The TOS and OSI levels were notably higher in the patients with a vascular-event history than in those without this history. CONCLUSION: Oxidative stress parameters were increased in PV patients.
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spelling pubmed-55868752017-11-01 The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress Durmus, Ahmet Mentese, Ahmet Yilmaz, Mustafa Sumer, Aysegul Akalin, Ibrahim Topal, Cevat Alver, Ahmet Med Princ Pract Original Paper OBJECTIVE: This study was designed to compare the oxidative stress parameters of patients with polycythemia vera (PV) to those of healthy volunteers and to investigate the probable relationship between vascular events and parameters of oxidative status such as total oxidative status (TOS), total antioxidant status, oxidative stress index (OSI) and malondialdehyde (MDA) in PV patients. MATERIAL AND METHODS: Thirty-five PV patients (20 males and 15 females) and 20 healthy volunteers (11 males and 9 females) were enrolled. The oxidative status parameters of the patients were measured by spectrophotometric analyses at the time of diagnosis and at 6 months after treatment which consisted of phlebotomy and 100 mg/day acetyl salicylic acid with or without hydroxyurea for the high- and low-risk disease group, respectively. These parameters were compared both to healthy controls and to each other, in order to obtain the values before and after treatment. In addition, during diagnosis, the oxidative status parameters of patients with PV and a history of a vascular event were compared with those of patients with no history of a vascular event. RESULTS: The TOS, OSI and MDA values were significantly higher in the patients than in the control group at the time of diagnosis. At 6 months after phlebotomy and 100 mg/day acetyl salicylic acid therapy, the TOS, OSI and MDA values were significantly lower in the patients when compared to the pretreatment values. The TOS and OSI levels were notably higher in the patients with a vascular-event history than in those without this history. CONCLUSION: Oxidative stress parameters were increased in PV patients. S. Karger AG 2014-05 2014-03-15 /pmc/articles/PMC5586875/ /pubmed/24642873 http://dx.doi.org/10.1159/000360102 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Original Paper
Durmus, Ahmet
Mentese, Ahmet
Yilmaz, Mustafa
Sumer, Aysegul
Akalin, Ibrahim
Topal, Cevat
Alver, Ahmet
The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress
title The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress
title_full The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress
title_fullStr The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress
title_full_unstemmed The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress
title_short The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress
title_sort thrombotic events in polycythemia vera patients may be related to increased oxidative stress
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586875/
https://www.ncbi.nlm.nih.gov/pubmed/24642873
http://dx.doi.org/10.1159/000360102
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