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Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure
OBJECTIVE: It was the aim of this study to investigate the serum oxidative stress level in nonischemic patients with heart failure (HF). SUBJECTS AND METHODS: The study included 37 patients who presented to the Department of Cardiology, Suleyman Demirel University, Isparta, Turkey, with a diagnosis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586961/ https://www.ncbi.nlm.nih.gov/pubmed/25195646 http://dx.doi.org/10.1159/000365512 |
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author | Karabacak, Mustafa Dogan, Abdullah Tayyar, Senol Bas, Hasan Aydın |
author_facet | Karabacak, Mustafa Dogan, Abdullah Tayyar, Senol Bas, Hasan Aydın |
author_sort | Karabacak, Mustafa |
collection | PubMed |
description | OBJECTIVE: It was the aim of this study to investigate the serum oxidative stress level in nonischemic patients with heart failure (HF). SUBJECTS AND METHODS: The study included 37 patients who presented to the Department of Cardiology, Suleyman Demirel University, Isparta, Turkey, with a diagnosis of asymptomatic HF (New York Heart Association class I-II). The patients had a left ventricular (LV) ejection fraction (EF) of ≤40% and normal coronary arteries or nonsignificant stenosis (stenosis <40%). In addition, 30 age- and sex-matched normal patients were selected as the control group. Clinical and laboratory characteristics presumed to be associated with oxidative stress were evaluated. RESULTS: Demographic characteristics were comparable. However, creatinine and potassium levels were higher in the HF than in the control group. Total oxidative status [2.42 μmol H(2)O(2) Eq/l (range 0.74–5.86) vs. 1.81 μmol H(2)O(2) Eq/l (range 0.42–3.45); p < 0.01], oxidative stress index [2.24 (range 0.63–5.33) vs. 1.53 (range 0.28–2.51); p < 0.01] and uric acid (6.1 ± 1.8 vs. 4.4 ± 1.1 mg/dl; p < 0.01) levels were significantly higher in the HF than in the control group. The total antioxidant capacity was similar in both groups [1.22 mmol Trolox Eq/l (range 0.61–1.99) vs. 1.18 mmol Trolox Eq/l (range 0.82–1.80); p = 0.77]. The γ-glutamyltransferase levels were also comparable in both groups [32 U/l (range 11–106) vs. 23 U/l (range 11–72); p = 0.10]. CONCLUSION: The oxidative stress levels were higher in HF patients, and hence, oxidative stress may play an important role in poor prognosis of HF. Therefore, antioxidant treatment might be reasonable. |
format | Online Article Text |
id | pubmed-5586961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-55869612017-11-01 Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure Karabacak, Mustafa Dogan, Abdullah Tayyar, Senol Bas, Hasan Aydın Med Princ Pract Original Paper OBJECTIVE: It was the aim of this study to investigate the serum oxidative stress level in nonischemic patients with heart failure (HF). SUBJECTS AND METHODS: The study included 37 patients who presented to the Department of Cardiology, Suleyman Demirel University, Isparta, Turkey, with a diagnosis of asymptomatic HF (New York Heart Association class I-II). The patients had a left ventricular (LV) ejection fraction (EF) of ≤40% and normal coronary arteries or nonsignificant stenosis (stenosis <40%). In addition, 30 age- and sex-matched normal patients were selected as the control group. Clinical and laboratory characteristics presumed to be associated with oxidative stress were evaluated. RESULTS: Demographic characteristics were comparable. However, creatinine and potassium levels were higher in the HF than in the control group. Total oxidative status [2.42 μmol H(2)O(2) Eq/l (range 0.74–5.86) vs. 1.81 μmol H(2)O(2) Eq/l (range 0.42–3.45); p < 0.01], oxidative stress index [2.24 (range 0.63–5.33) vs. 1.53 (range 0.28–2.51); p < 0.01] and uric acid (6.1 ± 1.8 vs. 4.4 ± 1.1 mg/dl; p < 0.01) levels were significantly higher in the HF than in the control group. The total antioxidant capacity was similar in both groups [1.22 mmol Trolox Eq/l (range 0.61–1.99) vs. 1.18 mmol Trolox Eq/l (range 0.82–1.80); p = 0.77]. The γ-glutamyltransferase levels were also comparable in both groups [32 U/l (range 11–106) vs. 23 U/l (range 11–72); p = 0.10]. CONCLUSION: The oxidative stress levels were higher in HF patients, and hence, oxidative stress may play an important role in poor prognosis of HF. Therefore, antioxidant treatment might be reasonable. S. Karger AG 2014-11 2014-09-03 /pmc/articles/PMC5586961/ /pubmed/25195646 http://dx.doi.org/10.1159/000365512 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only. |
spellingShingle | Original Paper Karabacak, Mustafa Dogan, Abdullah Tayyar, Senol Bas, Hasan Aydın Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure |
title | Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure |
title_full | Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure |
title_fullStr | Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure |
title_full_unstemmed | Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure |
title_short | Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure |
title_sort | oxidative stress status increase in patients with nonischemic heart failure |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586961/ https://www.ncbi.nlm.nih.gov/pubmed/25195646 http://dx.doi.org/10.1159/000365512 |
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