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Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure

OBJECTIVE: It was the aim of this study to investigate the serum oxidative stress level in nonischemic patients with heart failure (HF). SUBJECTS AND METHODS: The study included 37 patients who presented to the Department of Cardiology, Suleyman Demirel University, Isparta, Turkey, with a diagnosis...

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Autores principales: Karabacak, Mustafa, Dogan, Abdullah, Tayyar, Senol, Bas, Hasan Aydın
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586961/
https://www.ncbi.nlm.nih.gov/pubmed/25195646
http://dx.doi.org/10.1159/000365512
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author Karabacak, Mustafa
Dogan, Abdullah
Tayyar, Senol
Bas, Hasan Aydın
author_facet Karabacak, Mustafa
Dogan, Abdullah
Tayyar, Senol
Bas, Hasan Aydın
author_sort Karabacak, Mustafa
collection PubMed
description OBJECTIVE: It was the aim of this study to investigate the serum oxidative stress level in nonischemic patients with heart failure (HF). SUBJECTS AND METHODS: The study included 37 patients who presented to the Department of Cardiology, Suleyman Demirel University, Isparta, Turkey, with a diagnosis of asymptomatic HF (New York Heart Association class I-II). The patients had a left ventricular (LV) ejection fraction (EF) of ≤40% and normal coronary arteries or nonsignificant stenosis (stenosis <40%). In addition, 30 age- and sex-matched normal patients were selected as the control group. Clinical and laboratory characteristics presumed to be associated with oxidative stress were evaluated. RESULTS: Demographic characteristics were comparable. However, creatinine and potassium levels were higher in the HF than in the control group. Total oxidative status [2.42 μmol H(2)O(2) Eq/l (range 0.74–5.86) vs. 1.81 μmol H(2)O(2) Eq/l (range 0.42–3.45); p < 0.01], oxidative stress index [2.24 (range 0.63–5.33) vs. 1.53 (range 0.28–2.51); p < 0.01] and uric acid (6.1 ± 1.8 vs. 4.4 ± 1.1 mg/dl; p < 0.01) levels were significantly higher in the HF than in the control group. The total antioxidant capacity was similar in both groups [1.22 mmol Trolox Eq/l (range 0.61–1.99) vs. 1.18 mmol Trolox Eq/l (range 0.82–1.80); p = 0.77]. The γ-glutamyltransferase levels were also comparable in both groups [32 U/l (range 11–106) vs. 23 U/l (range 11–72); p = 0.10]. CONCLUSION: The oxidative stress levels were higher in HF patients, and hence, oxidative stress may play an important role in poor prognosis of HF. Therefore, antioxidant treatment might be reasonable.
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spelling pubmed-55869612017-11-01 Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure Karabacak, Mustafa Dogan, Abdullah Tayyar, Senol Bas, Hasan Aydın Med Princ Pract Original Paper OBJECTIVE: It was the aim of this study to investigate the serum oxidative stress level in nonischemic patients with heart failure (HF). SUBJECTS AND METHODS: The study included 37 patients who presented to the Department of Cardiology, Suleyman Demirel University, Isparta, Turkey, with a diagnosis of asymptomatic HF (New York Heart Association class I-II). The patients had a left ventricular (LV) ejection fraction (EF) of ≤40% and normal coronary arteries or nonsignificant stenosis (stenosis <40%). In addition, 30 age- and sex-matched normal patients were selected as the control group. Clinical and laboratory characteristics presumed to be associated with oxidative stress were evaluated. RESULTS: Demographic characteristics were comparable. However, creatinine and potassium levels were higher in the HF than in the control group. Total oxidative status [2.42 μmol H(2)O(2) Eq/l (range 0.74–5.86) vs. 1.81 μmol H(2)O(2) Eq/l (range 0.42–3.45); p < 0.01], oxidative stress index [2.24 (range 0.63–5.33) vs. 1.53 (range 0.28–2.51); p < 0.01] and uric acid (6.1 ± 1.8 vs. 4.4 ± 1.1 mg/dl; p < 0.01) levels were significantly higher in the HF than in the control group. The total antioxidant capacity was similar in both groups [1.22 mmol Trolox Eq/l (range 0.61–1.99) vs. 1.18 mmol Trolox Eq/l (range 0.82–1.80); p = 0.77]. The γ-glutamyltransferase levels were also comparable in both groups [32 U/l (range 11–106) vs. 23 U/l (range 11–72); p = 0.10]. CONCLUSION: The oxidative stress levels were higher in HF patients, and hence, oxidative stress may play an important role in poor prognosis of HF. Therefore, antioxidant treatment might be reasonable. S. Karger AG 2014-11 2014-09-03 /pmc/articles/PMC5586961/ /pubmed/25195646 http://dx.doi.org/10.1159/000365512 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Original Paper
Karabacak, Mustafa
Dogan, Abdullah
Tayyar, Senol
Bas, Hasan Aydın
Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure
title Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure
title_full Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure
title_fullStr Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure
title_full_unstemmed Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure
title_short Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure
title_sort oxidative stress status increase in patients with nonischemic heart failure
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586961/
https://www.ncbi.nlm.nih.gov/pubmed/25195646
http://dx.doi.org/10.1159/000365512
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