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Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa

PURPOSE: Sigma 1 Receptor (Sig1R) is a novel therapeutic target in neurodegenerative diseases, including retinal disease. Sig1R(−/−) mice have late-onset retinal degeneration with ganglion cell loss that worsens under stress. Whether Sig1R plays a role in maintaining other retinal neurons is unknown...

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Detalles Bibliográficos
Autores principales:	Wang, Jing, Saul, Alan, Cui, Xuezhi, Roon, Penny, Smith, Sylvia B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2017
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586962/ https://www.ncbi.nlm.nih.gov/pubmed/28877319 http://dx.doi.org/10.1167/iovs.17-21947

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