A case of schizophrenia comorbid for tetralogy of Fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures

We present a case of schizophrenia comorbid for tetralogy of Fallot, without chromosome 22q.11.2 deletion or duplication, treated successfully with a combination of clozapine and antiepileptic drugs. Although clozapine by itself initially triggered convulsive seizures, we continued it with co-admini...

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Autores principales: Kashiwagi, Hiroko, Ikezawa, Satoru, Sumiyoshi, Tomiki, Kadono, Atsuko, Segawa, Kazuhiko, Takeda, Kazuyoshi, Omori, Mayu, Taguchi, Hisako, Hirabayashi, Naotsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587213/
https://www.ncbi.nlm.nih.gov/pubmed/28919758
http://dx.doi.org/10.2147/NDT.S144212
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author Kashiwagi, Hiroko
Ikezawa, Satoru
Sumiyoshi, Tomiki
Kadono, Atsuko
Segawa, Kazuhiko
Takeda, Kazuyoshi
Omori, Mayu
Taguchi, Hisako
Hirabayashi, Naotsugu
author_facet Kashiwagi, Hiroko
Ikezawa, Satoru
Sumiyoshi, Tomiki
Kadono, Atsuko
Segawa, Kazuhiko
Takeda, Kazuyoshi
Omori, Mayu
Taguchi, Hisako
Hirabayashi, Naotsugu
author_sort Kashiwagi, Hiroko
collection PubMed
description We present a case of schizophrenia comorbid for tetralogy of Fallot, without chromosome 22q.11.2 deletion or duplication, treated successfully with a combination of clozapine and antiepileptic drugs. Although clozapine by itself initially triggered convulsive seizures, we continued it with co-administration of valproate and topiramate. This combined treatment did not affect cardiac function of the patient, who experienced a favorable clinical course in terms of symptomatology and functional outcomes. To our knowledge, we provide the first report on a patient with tetralogy of Fallot, in whom 22q.11.2 was not deleted and clozapine-induced seizures were observed.
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spelling pubmed-55872132017-09-15 A case of schizophrenia comorbid for tetralogy of Fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures Kashiwagi, Hiroko Ikezawa, Satoru Sumiyoshi, Tomiki Kadono, Atsuko Segawa, Kazuhiko Takeda, Kazuyoshi Omori, Mayu Taguchi, Hisako Hirabayashi, Naotsugu Neuropsychiatr Dis Treat Case Report We present a case of schizophrenia comorbid for tetralogy of Fallot, without chromosome 22q.11.2 deletion or duplication, treated successfully with a combination of clozapine and antiepileptic drugs. Although clozapine by itself initially triggered convulsive seizures, we continued it with co-administration of valproate and topiramate. This combined treatment did not affect cardiac function of the patient, who experienced a favorable clinical course in terms of symptomatology and functional outcomes. To our knowledge, we provide the first report on a patient with tetralogy of Fallot, in whom 22q.11.2 was not deleted and clozapine-induced seizures were observed. Dove Medical Press 2017-08-29 /pmc/articles/PMC5587213/ /pubmed/28919758 http://dx.doi.org/10.2147/NDT.S144212 Text en © 2017 Kashiwagi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Kashiwagi, Hiroko
Ikezawa, Satoru
Sumiyoshi, Tomiki
Kadono, Atsuko
Segawa, Kazuhiko
Takeda, Kazuyoshi
Omori, Mayu
Taguchi, Hisako
Hirabayashi, Naotsugu
A case of schizophrenia comorbid for tetralogy of Fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures
title A case of schizophrenia comorbid for tetralogy of Fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures
title_full A case of schizophrenia comorbid for tetralogy of Fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures
title_fullStr A case of schizophrenia comorbid for tetralogy of Fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures
title_full_unstemmed A case of schizophrenia comorbid for tetralogy of Fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures
title_short A case of schizophrenia comorbid for tetralogy of Fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures
title_sort case of schizophrenia comorbid for tetralogy of fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587213/
https://www.ncbi.nlm.nih.gov/pubmed/28919758
http://dx.doi.org/10.2147/NDT.S144212
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