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Preventable proportion of intubation-associated pneumonia: Role of adherence to a care bundle
OBJECTIVE: The aim of the present study was to estimate the preventable proportion of Intubation-Associated Pneumonia (IAP) in the Intensive Care Units (ICUs) participating in the Italian Nosocomial Infections Surveillance in ICUs (SPIN-UTI) network, taking into account differences in intrinsic pati...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587225/ https://www.ncbi.nlm.nih.gov/pubmed/28877171 http://dx.doi.org/10.1371/journal.pone.0181170 |
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author | Agodi, Antonella Barchitta, Martina Quattrocchi, Annalisa Spera, Emiliano Gallo, Giovanni Auxilia, Francesco Brusaferro, Silvio D’Errico, Marcello Mario Montagna, Maria Teresa Pasquarella, Cesira Tardivo, Stefano Mura, Ida |
author_facet | Agodi, Antonella Barchitta, Martina Quattrocchi, Annalisa Spera, Emiliano Gallo, Giovanni Auxilia, Francesco Brusaferro, Silvio D’Errico, Marcello Mario Montagna, Maria Teresa Pasquarella, Cesira Tardivo, Stefano Mura, Ida |
author_sort | Agodi, Antonella |
collection | PubMed |
description | OBJECTIVE: The aim of the present study was to estimate the preventable proportion of Intubation-Associated Pneumonia (IAP) in the Intensive Care Units (ICUs) participating in the Italian Nosocomial Infections Surveillance in ICUs (SPIN-UTI) network, taking into account differences in intrinsic patients’ risk factors, and additionally considering the compliance with the European bundle for IAP prevention. METHODS: A prospective patient-based survey was conducted and all patients staying in ICU for more than 2 days were enrolled in the surveillance. Compliance with the bundle was assessed using a questionnaire for each intubated patient. A twofold analysis by the parametric g-formula was used to compute the number of infections to be expected if the infection incidence in all ICUs could be reduced to that one of the top-tenth-percentile-ranked ICUs and to that one of the ICU with the highest compliance to all five bundle components. RESULTS: A total of 1,840 patients and of 17 ICUs were included in the first analysis showing a preventable proportion of 44% of IAP. In a second analysis on a subset of data, considering compliance with the European bundle, a preventable proportion of 40% of IAP was shown. A significant negative trend of IAP incidences was observed with increasing number of bundle components performed (p<0.001) and a strong negative correlation between these two factors was shown (r = -0.882; p = 0.048). CONCLUSIONS: The g-formula controlled for time-varying factors is a valuable approach for estimating the preventable proportion of IAP and the impact of interventions, based entirely on an observed population in a real-world setting. However, both the study design that cannot definitively prove a causative relationship between bundle compliance and IAP risk, and the small number of patients included in the care bundle compliance analysis, may represent limits of the study and further and larger studies should be conducted. |
format | Online Article Text |
id | pubmed-5587225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55872252017-09-15 Preventable proportion of intubation-associated pneumonia: Role of adherence to a care bundle Agodi, Antonella Barchitta, Martina Quattrocchi, Annalisa Spera, Emiliano Gallo, Giovanni Auxilia, Francesco Brusaferro, Silvio D’Errico, Marcello Mario Montagna, Maria Teresa Pasquarella, Cesira Tardivo, Stefano Mura, Ida PLoS One Research Article OBJECTIVE: The aim of the present study was to estimate the preventable proportion of Intubation-Associated Pneumonia (IAP) in the Intensive Care Units (ICUs) participating in the Italian Nosocomial Infections Surveillance in ICUs (SPIN-UTI) network, taking into account differences in intrinsic patients’ risk factors, and additionally considering the compliance with the European bundle for IAP prevention. METHODS: A prospective patient-based survey was conducted and all patients staying in ICU for more than 2 days were enrolled in the surveillance. Compliance with the bundle was assessed using a questionnaire for each intubated patient. A twofold analysis by the parametric g-formula was used to compute the number of infections to be expected if the infection incidence in all ICUs could be reduced to that one of the top-tenth-percentile-ranked ICUs and to that one of the ICU with the highest compliance to all five bundle components. RESULTS: A total of 1,840 patients and of 17 ICUs were included in the first analysis showing a preventable proportion of 44% of IAP. In a second analysis on a subset of data, considering compliance with the European bundle, a preventable proportion of 40% of IAP was shown. A significant negative trend of IAP incidences was observed with increasing number of bundle components performed (p<0.001) and a strong negative correlation between these two factors was shown (r = -0.882; p = 0.048). CONCLUSIONS: The g-formula controlled for time-varying factors is a valuable approach for estimating the preventable proportion of IAP and the impact of interventions, based entirely on an observed population in a real-world setting. However, both the study design that cannot definitively prove a causative relationship between bundle compliance and IAP risk, and the small number of patients included in the care bundle compliance analysis, may represent limits of the study and further and larger studies should be conducted. Public Library of Science 2017-09-06 /pmc/articles/PMC5587225/ /pubmed/28877171 http://dx.doi.org/10.1371/journal.pone.0181170 Text en © 2017 Agodi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Agodi, Antonella Barchitta, Martina Quattrocchi, Annalisa Spera, Emiliano Gallo, Giovanni Auxilia, Francesco Brusaferro, Silvio D’Errico, Marcello Mario Montagna, Maria Teresa Pasquarella, Cesira Tardivo, Stefano Mura, Ida Preventable proportion of intubation-associated pneumonia: Role of adherence to a care bundle |
title | Preventable proportion of intubation-associated pneumonia: Role of adherence to a care bundle |
title_full | Preventable proportion of intubation-associated pneumonia: Role of adherence to a care bundle |
title_fullStr | Preventable proportion of intubation-associated pneumonia: Role of adherence to a care bundle |
title_full_unstemmed | Preventable proportion of intubation-associated pneumonia: Role of adherence to a care bundle |
title_short | Preventable proportion of intubation-associated pneumonia: Role of adherence to a care bundle |
title_sort | preventable proportion of intubation-associated pneumonia: role of adherence to a care bundle |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587225/ https://www.ncbi.nlm.nih.gov/pubmed/28877171 http://dx.doi.org/10.1371/journal.pone.0181170 |
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