Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes

BACKGROUND: Programmed death cell 1 (PD-1) is an inhibitor of T cell activation and is also functionally linked to glycolysis. We hypothesized that PD-1 expression is defective in activated T cells from children with type 1 diabetes (T1D), resulting in abnormal T cell glucose metabolism. METHODS: In...

Descripción completa

Detalles Bibliográficos
Autores principales: Granados, Hector M., Draghi, Andrew, Tsurutani, Naomi, Wright, Kyle, Fernandez, Marina L., Sylvester, Francisco A., Vella, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587274/
https://www.ncbi.nlm.nih.gov/pubmed/28877189
http://dx.doi.org/10.1371/journal.pone.0183887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587274/
https://www.ncbi.nlm.nih.gov/pubmed/28877189
http://dx.doi.org/10.1371/journal.pone.0183887

Ejemplares similares