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Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes

BACKGROUND: Programmed death cell 1 (PD-1) is an inhibitor of T cell activation and is also functionally linked to glycolysis. We hypothesized that PD-1 expression is defective in activated T cells from children with type 1 diabetes (T1D), resulting in abnormal T cell glucose metabolism. METHODS: In...

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Detalles Bibliográficos
Autores principales:	Granados, Hector M., Draghi, Andrew, Tsurutani, Naomi, Wright, Kyle, Fernandez, Marina L., Sylvester, Francisco A., Vella, Anthony T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587274/ https://www.ncbi.nlm.nih.gov/pubmed/28877189 http://dx.doi.org/10.1371/journal.pone.0183887

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