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Simulation framework for generating intratumor heterogeneity patterns in a cancer cell population
As cancer cell populations evolve, they accumulate a number of somatic mutations, resulting in heterogeneous subclones in the final tumor. Understanding the mechanisms that produce intratumor heterogeneity is important for selecting the best treatment. Although some studies have involved intratumor...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587296/ https://www.ncbi.nlm.nih.gov/pubmed/28877206 http://dx.doi.org/10.1371/journal.pone.0184229 |