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Involvement of arginine 878 together with Ca(2+) in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues

Aminopeptidase A (APA) is a membrane-bound zinc metalloprotease cleaving, in the brain, the N-terminal aspartyl residue of angiotensin II to generate angiotensin III, which exerts a tonic stimulatory effect on the control of blood pressure in hypertensive animals. Using a refined APA structure deriv...

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Detalles Bibliográficos
Autores principales:	Couvineau, Pierre, de Almeida, Hugo, Maigret, Bernard, Llorens-Cortes, Catherine, Iturrioz, Xavier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587309/ https://www.ncbi.nlm.nih.gov/pubmed/28877217 http://dx.doi.org/10.1371/journal.pone.0184237

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