The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome

Abnormal accumulation of α-synuclein (αSyn) has been linked to endoplasmic-reticulum (ER) stress, defective intracellular protein/vesicle trafficking, and cytotoxicity. Targeting factors involved in ER-related protein processing and trafficking may, therefore, be a key to modulating αSyn levels and...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Hyo-Jin, Ryu, Daniel, Parmar, Mayur, Giasson, Benoit I., McFarland, Nikolaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587320/
https://www.ncbi.nlm.nih.gov/pubmed/28877262
http://dx.doi.org/10.1371/journal.pone.0184262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587320/
https://www.ncbi.nlm.nih.gov/pubmed/28877262
http://dx.doi.org/10.1371/journal.pone.0184262

Ejemplares similares