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Influenza NS1 directly modulates Hedgehog signaling during infection

The multifunctional NS1 protein of influenza A viruses suppresses host cellular defense mechanisms and subverts other cellular functions. We report here on a new role for NS1 in modifying cell-cell signaling via the Hedgehog (Hh) pathway. Genetic epistasis experiments and FRET-FLIM assays in Drosoph...

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Detalles Bibliográficos
Autores principales:	Smelkinson, Margery G., Guichard, Annabel, Teijaro, John R., Malur, Meghana, Loureiro, Maria Eugenia, Jain, Prashant, Ganesan, Sundar, Zúñiga, Elina I., Krug, Robert M., Oldstone, Michael B., Bier, Ethan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587344/ https://www.ncbi.nlm.nih.gov/pubmed/28837667 http://dx.doi.org/10.1371/journal.ppat.1006588

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