RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury

Traumatic brain injury (TBI) causes extensive neural damage, often resulting in long-term cognitive impairments. Unfortunately, effective treatments for TBI remain elusive. The RhoA-ROCK signaling pathway is a potential therapeutic target since it is activated by TBI and can promote the retraction o...

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Detalles Bibliográficos
Autores principales: Mulherkar, Shalaka, Firozi, Karen, Huang, Wei, Uddin, Mohammad Danish, Grill, Raymond J., Costa-Mattioli, Mauro, Robertson, Claudia, Tolias, Kimberley F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587534/
https://www.ncbi.nlm.nih.gov/pubmed/28878396
http://dx.doi.org/10.1038/s41598-017-11113-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587534/
https://www.ncbi.nlm.nih.gov/pubmed/28878396
http://dx.doi.org/10.1038/s41598-017-11113-3

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