Swapping of transmembrane domains in the epithelial calcium channel TRPV6

Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping...

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Autores principales: Singh, Appu K., Saotome, Kei, Sobolevsky, Alexander I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587609/
https://www.ncbi.nlm.nih.gov/pubmed/28878326
http://dx.doi.org/10.1038/s41598-017-10993-9
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author Singh, Appu K.
Saotome, Kei
Sobolevsky, Alexander I.
author_facet Singh, Appu K.
Saotome, Kei
Sobolevsky, Alexander I.
author_sort Singh, Appu K.
collection PubMed
description Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.
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spelling pubmed-55876092017-09-13 Swapping of transmembrane domains in the epithelial calcium channel TRPV6 Singh, Appu K. Saotome, Kei Sobolevsky, Alexander I. Sci Rep Article Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states. Nature Publishing Group UK 2017-09-06 /pmc/articles/PMC5587609/ /pubmed/28878326 http://dx.doi.org/10.1038/s41598-017-10993-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Singh, Appu K.
Saotome, Kei
Sobolevsky, Alexander I.
Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title_full Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title_fullStr Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title_full_unstemmed Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title_short Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title_sort swapping of transmembrane domains in the epithelial calcium channel trpv6
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587609/
https://www.ncbi.nlm.nih.gov/pubmed/28878326
http://dx.doi.org/10.1038/s41598-017-10993-9
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