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mRNA cap analogues substituted in the tetraphosphate chain with CX(2): identification of O-to-CCl(2) as the first bridging modification that confers resistance to decapping without impairing translation

Analogues of the mRNA 5′-cap are useful tools for studying mRNA translation and degradation, with emerging potential applications in novel therapeutic interventions including gene therapy. We report the synthesis of novel mono- and dinucleotide cap analogues containing dihalogenmethylenebisphosphona...

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Detalles Bibliográficos
Autores principales:	Rydzik, Anna M., Warminski, Marcin, Sikorski, Pawel J., Baranowski, Marek R., Walczak, Sylwia, Kowalska, Joanna, Zuberek, Joanna, Lukaszewicz, Maciej, Nowak, Elzbieta, W. Claridge, Timothy D., Darzynkiewicz, Edward, Nowotny, Marcin, Jemielity, Jacek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587727/ https://www.ncbi.nlm.nih.gov/pubmed/28666355 http://dx.doi.org/10.1093/nar/gkx569

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