Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases

Polyadenylation of nascent RNA by poly(A) polymerase (PAP) is important for 3′ end maturation of almost all eukaryotic mRNAs. Most mammalian genes harbor multiple polyadenylation sites (PASs), leading to expression of alternative polyadenylation (APA) isoforms with distinct functions. How poly(A) po...

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Detalles Bibliográficos
Autores principales: Li, Weimin, Li, Wencheng, Laishram, Rakesh S., Hoque, Mainul, Ji, Zhe, Tian, Bin, Anderson, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587728/
https://www.ncbi.nlm.nih.gov/pubmed/28911096
http://dx.doi.org/10.1093/nar/gkx560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587728/
https://www.ncbi.nlm.nih.gov/pubmed/28911096
http://dx.doi.org/10.1093/nar/gkx560

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