The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoietic transplant

Salp15, a salivary protein of Ixodes ticks, inhibits the activation of naïve CD4 T cells. Treatment with Salp15 results in the inhibition of early signaling events and the production of the autocrine growth factor, interleukin-2. The fate of the CD4 T cells activated in the presence of Salp15 or its...

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Detalles Bibliográficos
Autores principales: Tomás-Cortázar, Julen, Martín-Ruiz, Itziar, Barriales, Diego, Pascual-Itoiz, Miguel Ángel, de Juan, Virginia Gutiérrez, Caro-Maldonado, Alfredo, Merino, Nekane, Marina, Alberto, Blanco, Francisco J., Flores, Juana María, Sutherland, James D., Barrio, Rosa, Rojas, Adriana, Martínez-Chantar, María Luz, Carracedo, Arkaitz, Simó, Carolina, García-Cañas, Virginia, Abecia, Leticia, Lavín, José Luis, Aransay, Ana M., Rodríguez, Héctor, Anguita, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587732/
https://www.ncbi.nlm.nih.gov/pubmed/28878331
http://dx.doi.org/10.1038/s41598-017-11354-2

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