CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level

The methylcytosine-binding domain 2 (MBD2) protein recruits the nucleosome remodeling and deacetylase complex (NuRD) to methylated DNA to modify chromatin and regulate transcription. Importantly, MBD2 functions within CpG islands that contain 100s to 1000s of potential binding sites. Since NuRD phys...

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Detalles Bibliográficos
Autores principales: Pan, Hai, Bilinovich, Stephanie M., Kaur, Parminder, Riehn, Robert, Wang, Hong, Williams, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587734/
https://www.ncbi.nlm.nih.gov/pubmed/28637186
http://dx.doi.org/10.1093/nar/gkx548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587734/
https://www.ncbi.nlm.nih.gov/pubmed/28637186
http://dx.doi.org/10.1093/nar/gkx548

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