A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination

RPA-coated single-stranded DNA (RPA–ssDNA), a nucleoprotein structure induced by DNA damage, promotes ATR activation and homologous recombination (HR). RPA is hyper-phosphorylated and ubiquitylated after DNA damage. The ubiquitylation of RPA by PRP19 and RFWD3 facilitates ATR activation and HR, but...

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Detalles Bibliográficos
Autores principales: Dubois, Jean-Christophe, Yates, Maïlyn, Gaudreau-Lapierre, Antoine, Clément, Geneviève, Cappadocia, Laurent, Gaudreau, Luc, Zou, Lee, Maréchal, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587784/
https://www.ncbi.nlm.nih.gov/pubmed/28666352
http://dx.doi.org/10.1093/nar/gkx571

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