Data on scaling up and in vivo human study of progesterone lipid nanoparticles

Progesterone containing nanoparticles constituted of tristearin or tristearin in association with caprylic-capric triglyceride were produced in a lab scale by ultrasound homogenization and in a pilot scale by high pressure homogenization. A study was conducted to select the pressure to be used in or...

Descripción completa

Detalles Bibliográficos
Autores principales: Esposito, Elisabetta, Sguizzato, Maddalena, Drechsler, Markus, Mariani, Paolo, Carducci, Federica, Nastruzzi, Claudio, Cortesi, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Pharmacology, Toxicology and Pharmaceutical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587877/
https://www.ncbi.nlm.nih.gov/pubmed/28913392
http://dx.doi.org/10.1016/j.dib.2017.08.033
_version_ 1783262076680011776
author Esposito, Elisabetta
Sguizzato, Maddalena
Drechsler, Markus
Mariani, Paolo
Carducci, Federica
Nastruzzi, Claudio
Cortesi, Rita
author_facet Esposito, Elisabetta
Sguizzato, Maddalena
Drechsler, Markus
Mariani, Paolo
Carducci, Federica
Nastruzzi, Claudio
Cortesi, Rita
author_sort Esposito, Elisabetta
collection PubMed
description Progesterone containing nanoparticles constituted of tristearin or tristearin in association with caprylic-capric triglyceride were produced in a lab scale by ultrasound homogenization and in a pilot scale by high pressure homogenization. A study was conducted to select the pressure to be used in order to obtain homogenously sized nanoparticles. The Dialysis method was performed to mimic subcutaneous administration of lipid nanoparticles. Mathematical analyses of the results were conducted to understand and compare the drug release mechanisms. A human in vivo study, based on tape stripping, was conducted to investigate the performance of nanoparticles as progesterone skin delivery systems. Tape stripped stratum corneum was analyzed by light microscopy.
format Online
Article
Text
id pubmed-5587877
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-55878772017-09-14 Data on scaling up and in vivo human study of progesterone lipid nanoparticles Esposito, Elisabetta Sguizzato, Maddalena Drechsler, Markus Mariani, Paolo Carducci, Federica Nastruzzi, Claudio Cortesi, Rita Data Brief Pharmacology, Toxicology and Pharmaceutical Science Progesterone containing nanoparticles constituted of tristearin or tristearin in association with caprylic-capric triglyceride were produced in a lab scale by ultrasound homogenization and in a pilot scale by high pressure homogenization. A study was conducted to select the pressure to be used in order to obtain homogenously sized nanoparticles. The Dialysis method was performed to mimic subcutaneous administration of lipid nanoparticles. Mathematical analyses of the results were conducted to understand and compare the drug release mechanisms. A human in vivo study, based on tape stripping, was conducted to investigate the performance of nanoparticles as progesterone skin delivery systems. Tape stripped stratum corneum was analyzed by light microscopy. Elsevier 2017-08-31 /pmc/articles/PMC5587877/ /pubmed/28913392 http://dx.doi.org/10.1016/j.dib.2017.08.033 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Pharmacology, Toxicology and Pharmaceutical Science
Esposito, Elisabetta
Sguizzato, Maddalena
Drechsler, Markus
Mariani, Paolo
Carducci, Federica
Nastruzzi, Claudio
Cortesi, Rita
Data on scaling up and in vivo human study of progesterone lipid nanoparticles
title Data on scaling up and in vivo human study of progesterone lipid nanoparticles
title_full Data on scaling up and in vivo human study of progesterone lipid nanoparticles
title_fullStr Data on scaling up and in vivo human study of progesterone lipid nanoparticles
title_full_unstemmed Data on scaling up and in vivo human study of progesterone lipid nanoparticles
title_short Data on scaling up and in vivo human study of progesterone lipid nanoparticles
title_sort data on scaling up and in vivo human study of progesterone lipid nanoparticles
topic Pharmacology, Toxicology and Pharmaceutical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587877/
https://www.ncbi.nlm.nih.gov/pubmed/28913392
http://dx.doi.org/10.1016/j.dib.2017.08.033
work_keys_str_mv AT espositoelisabetta dataonscalingupandinvivohumanstudyofprogesteronelipidnanoparticles
AT sguizzatomaddalena dataonscalingupandinvivohumanstudyofprogesteronelipidnanoparticles
AT drechslermarkus dataonscalingupandinvivohumanstudyofprogesteronelipidnanoparticles
AT marianipaolo dataonscalingupandinvivohumanstudyofprogesteronelipidnanoparticles
AT carduccifederica dataonscalingupandinvivohumanstudyofprogesteronelipidnanoparticles
AT nastruzziclaudio dataonscalingupandinvivohumanstudyofprogesteronelipidnanoparticles
AT cortesirita dataonscalingupandinvivohumanstudyofprogesteronelipidnanoparticles

Ejemplares similares