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The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model

Nonfocused low-intensity ultrasound is generally believed to be less efficacious than High-Intensity Focused Ultrasound (HIFU) at body fat reduction; nevertheless, this technology has already been widely used clinically for body contouring purposes. This study aimed to evaluate the efficacy and safe...

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Detalles Bibliográficos
Autores principales: Zhou, Bill, Leung, Benny Yuk Kin, Sun, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587957/
https://www.ncbi.nlm.nih.gov/pubmed/28913353
http://dx.doi.org/10.1155/2017/4701481
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author Zhou, Bill
Leung, Benny Yuk Kin
Sun, Lei
author_facet Zhou, Bill
Leung, Benny Yuk Kin
Sun, Lei
author_sort Zhou, Bill
collection PubMed
description Nonfocused low-intensity ultrasound is generally believed to be less efficacious than High-Intensity Focused Ultrasound (HIFU) at body fat reduction; nevertheless, this technology has already been widely used clinically for body contouring purposes. This study aimed to evaluate the efficacy and safety of this new technology by applying 1 MHz nonfocused ultrasound at 3 W/cm(2) to the outer-thigh region of rat models. Ultrasonography measurement demonstrated an average reduction of 0.5 mm of subcutaneous fat thickness that persisted for at least three days after treatment. Biochemical analysis quantified a significant increase in lipid levels, specifically triglyceride, high-density lipoprotein, and total cholesterol. These two findings of subcutaneous fat reduction and plasma lipid increase showed a positive correlation. No evidence of adverse events or complications was observed after the treatment. This study validated nonfocused low-intensity ultrasound as an effective and safe method for body fat reduction, especially with repetitive treatment. However, the concurrent increase in plasma lipid level will require further investigation to determine this technology's long-term impact, if any, on health.
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spelling pubmed-55879572017-09-14 The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model Zhou, Bill Leung, Benny Yuk Kin Sun, Lei Biomed Res Int Research Article Nonfocused low-intensity ultrasound is generally believed to be less efficacious than High-Intensity Focused Ultrasound (HIFU) at body fat reduction; nevertheless, this technology has already been widely used clinically for body contouring purposes. This study aimed to evaluate the efficacy and safety of this new technology by applying 1 MHz nonfocused ultrasound at 3 W/cm(2) to the outer-thigh region of rat models. Ultrasonography measurement demonstrated an average reduction of 0.5 mm of subcutaneous fat thickness that persisted for at least three days after treatment. Biochemical analysis quantified a significant increase in lipid levels, specifically triglyceride, high-density lipoprotein, and total cholesterol. These two findings of subcutaneous fat reduction and plasma lipid increase showed a positive correlation. No evidence of adverse events or complications was observed after the treatment. This study validated nonfocused low-intensity ultrasound as an effective and safe method for body fat reduction, especially with repetitive treatment. However, the concurrent increase in plasma lipid level will require further investigation to determine this technology's long-term impact, if any, on health. Hindawi 2017 2017-08-23 /pmc/articles/PMC5587957/ /pubmed/28913353 http://dx.doi.org/10.1155/2017/4701481 Text en Copyright © 2017 Bill Zhou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhou, Bill
Leung, Benny Yuk Kin
Sun, Lei
The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model
title The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model
title_full The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model
title_fullStr The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model
title_full_unstemmed The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model
title_short The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model
title_sort effects of low-intensity ultrasound on fat reduction of rat model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587957/
https://www.ncbi.nlm.nih.gov/pubmed/28913353
http://dx.doi.org/10.1155/2017/4701481
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