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The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model
Nonfocused low-intensity ultrasound is generally believed to be less efficacious than High-Intensity Focused Ultrasound (HIFU) at body fat reduction; nevertheless, this technology has already been widely used clinically for body contouring purposes. This study aimed to evaluate the efficacy and safe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587957/ https://www.ncbi.nlm.nih.gov/pubmed/28913353 http://dx.doi.org/10.1155/2017/4701481 |
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author | Zhou, Bill Leung, Benny Yuk Kin Sun, Lei |
author_facet | Zhou, Bill Leung, Benny Yuk Kin Sun, Lei |
author_sort | Zhou, Bill |
collection | PubMed |
description | Nonfocused low-intensity ultrasound is generally believed to be less efficacious than High-Intensity Focused Ultrasound (HIFU) at body fat reduction; nevertheless, this technology has already been widely used clinically for body contouring purposes. This study aimed to evaluate the efficacy and safety of this new technology by applying 1 MHz nonfocused ultrasound at 3 W/cm(2) to the outer-thigh region of rat models. Ultrasonography measurement demonstrated an average reduction of 0.5 mm of subcutaneous fat thickness that persisted for at least three days after treatment. Biochemical analysis quantified a significant increase in lipid levels, specifically triglyceride, high-density lipoprotein, and total cholesterol. These two findings of subcutaneous fat reduction and plasma lipid increase showed a positive correlation. No evidence of adverse events or complications was observed after the treatment. This study validated nonfocused low-intensity ultrasound as an effective and safe method for body fat reduction, especially with repetitive treatment. However, the concurrent increase in plasma lipid level will require further investigation to determine this technology's long-term impact, if any, on health. |
format | Online Article Text |
id | pubmed-5587957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55879572017-09-14 The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model Zhou, Bill Leung, Benny Yuk Kin Sun, Lei Biomed Res Int Research Article Nonfocused low-intensity ultrasound is generally believed to be less efficacious than High-Intensity Focused Ultrasound (HIFU) at body fat reduction; nevertheless, this technology has already been widely used clinically for body contouring purposes. This study aimed to evaluate the efficacy and safety of this new technology by applying 1 MHz nonfocused ultrasound at 3 W/cm(2) to the outer-thigh region of rat models. Ultrasonography measurement demonstrated an average reduction of 0.5 mm of subcutaneous fat thickness that persisted for at least three days after treatment. Biochemical analysis quantified a significant increase in lipid levels, specifically triglyceride, high-density lipoprotein, and total cholesterol. These two findings of subcutaneous fat reduction and plasma lipid increase showed a positive correlation. No evidence of adverse events or complications was observed after the treatment. This study validated nonfocused low-intensity ultrasound as an effective and safe method for body fat reduction, especially with repetitive treatment. However, the concurrent increase in plasma lipid level will require further investigation to determine this technology's long-term impact, if any, on health. Hindawi 2017 2017-08-23 /pmc/articles/PMC5587957/ /pubmed/28913353 http://dx.doi.org/10.1155/2017/4701481 Text en Copyright © 2017 Bill Zhou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhou, Bill Leung, Benny Yuk Kin Sun, Lei The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model |
title | The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model |
title_full | The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model |
title_fullStr | The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model |
title_full_unstemmed | The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model |
title_short | The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model |
title_sort | effects of low-intensity ultrasound on fat reduction of rat model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587957/ https://www.ncbi.nlm.nih.gov/pubmed/28913353 http://dx.doi.org/10.1155/2017/4701481 |
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