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New use of microsatellite instability analysis in endometrial cancer
The increasing incidence of obesity and diabetes due to changes in diet, earlier menarche, delayed menopause, late marriage, and declining birth rate have resulted in an increase in the number of endometrial cancer cases over the last few decades. Although surgical therapy is sufficient for early en...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587995/ https://www.ncbi.nlm.nih.gov/pubmed/28927079 http://dx.doi.org/10.3892/ol.2017.6640 |
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author | Kunitomi, Haruko Banno, Kouji Yanokura, Megumi Takeda, Takashi Iijima, Moito Nakamura, Kanako Iida, Miho Adachi, Masataka Watanabe, Keiko Matoba, Yusuke Kobayashi, Yusuke Tominaga, Eiichiro Aoki, Daisuke |
author_facet | Kunitomi, Haruko Banno, Kouji Yanokura, Megumi Takeda, Takashi Iijima, Moito Nakamura, Kanako Iida, Miho Adachi, Masataka Watanabe, Keiko Matoba, Yusuke Kobayashi, Yusuke Tominaga, Eiichiro Aoki, Daisuke |
author_sort | Kunitomi, Haruko |
collection | PubMed |
description | The increasing incidence of obesity and diabetes due to changes in diet, earlier menarche, delayed menopause, late marriage, and declining birth rate have resulted in an increase in the number of endometrial cancer cases over the last few decades. Although surgical therapy is sufficient for early endometrial cancer, there is no effective therapy for patients with advanced and recurrent endometrial cancer. The oncogenic mechanism of endometrial cancer involves microsatellite instability (MSI) caused by dysfunction of DNA mismatch repair genes in 30% of patients. Immune checkpoint inhibitors, including anti-programmed death (PD)-1 and anti-PD-ligand 1 antibodies, are of interest as novel anticancer drugs; however, these drugs are currently expensive, and there is a need to select patients who will benefit from their use. The use of MSI analysis as a predictive biomarker for the therapeutic efficacy of these drugs may be useful for reducing the costs of drug therapy. |
format | Online Article Text |
id | pubmed-5587995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-55879952017-09-18 New use of microsatellite instability analysis in endometrial cancer Kunitomi, Haruko Banno, Kouji Yanokura, Megumi Takeda, Takashi Iijima, Moito Nakamura, Kanako Iida, Miho Adachi, Masataka Watanabe, Keiko Matoba, Yusuke Kobayashi, Yusuke Tominaga, Eiichiro Aoki, Daisuke Oncol Lett Review The increasing incidence of obesity and diabetes due to changes in diet, earlier menarche, delayed menopause, late marriage, and declining birth rate have resulted in an increase in the number of endometrial cancer cases over the last few decades. Although surgical therapy is sufficient for early endometrial cancer, there is no effective therapy for patients with advanced and recurrent endometrial cancer. The oncogenic mechanism of endometrial cancer involves microsatellite instability (MSI) caused by dysfunction of DNA mismatch repair genes in 30% of patients. Immune checkpoint inhibitors, including anti-programmed death (PD)-1 and anti-PD-ligand 1 antibodies, are of interest as novel anticancer drugs; however, these drugs are currently expensive, and there is a need to select patients who will benefit from their use. The use of MSI analysis as a predictive biomarker for the therapeutic efficacy of these drugs may be useful for reducing the costs of drug therapy. D.A. Spandidos 2017-09 2017-07-20 /pmc/articles/PMC5587995/ /pubmed/28927079 http://dx.doi.org/10.3892/ol.2017.6640 Text en Copyright: © Kunitomi et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Kunitomi, Haruko Banno, Kouji Yanokura, Megumi Takeda, Takashi Iijima, Moito Nakamura, Kanako Iida, Miho Adachi, Masataka Watanabe, Keiko Matoba, Yusuke Kobayashi, Yusuke Tominaga, Eiichiro Aoki, Daisuke New use of microsatellite instability analysis in endometrial cancer |
title | New use of microsatellite instability analysis in endometrial cancer |
title_full | New use of microsatellite instability analysis in endometrial cancer |
title_fullStr | New use of microsatellite instability analysis in endometrial cancer |
title_full_unstemmed | New use of microsatellite instability analysis in endometrial cancer |
title_short | New use of microsatellite instability analysis in endometrial cancer |
title_sort | new use of microsatellite instability analysis in endometrial cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587995/ https://www.ncbi.nlm.nih.gov/pubmed/28927079 http://dx.doi.org/10.3892/ol.2017.6640 |
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