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Application of pirarubicin photosensitizer fluorescence cystoscopy in early detection of bladder cancer

The aim of this study was to investigate the value of pirarubicin (THP) photosensitizer fluorescence cystoscopy for the early diagnosis of bladder cancer. From January 2012 to June 2015, 25 patients with painless gross hematuria, were injected with THP 15 min prior to surgery and subsequently underw...

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Detalles Bibliográficos
Autores principales: Jiang, Bo, Dong, Yang, He, Houguang, Han, Conghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588036/
https://www.ncbi.nlm.nih.gov/pubmed/28927081
http://dx.doi.org/10.3892/ol.2017.6570
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author Jiang, Bo
Dong, Yang
He, Houguang
Han, Conghui
author_facet Jiang, Bo
Dong, Yang
He, Houguang
Han, Conghui
author_sort Jiang, Bo
collection PubMed
description The aim of this study was to investigate the value of pirarubicin (THP) photosensitizer fluorescence cystoscopy for the early diagnosis of bladder cancer. From January 2012 to June 2015, 25 patients with painless gross hematuria, were injected with THP 15 min prior to surgery and subsequently underwent fluorescence cystoscopy examination. Locations of tumors were recorded and biopsies were performed (total of 109 biopsies) under white and fluorescence light guidance. Biopsies were conducted at the THP-positive and -negative areas under white light and THP-positive areas under fluorescence light. Positive rate of bladder tumor tissue at the THP-positive areas detected under fluorescence light was 92.86%. The sensitivity and specificity were 100 and 96.15%, respectively. The positive rate of tumor tissue at the THP-positive areas detected under white light was 70.97%. The sensitivity and specificity were 100 and 84.74%, respectively. Fifty biopsies taken at the THP-negative areas under white light were found to be non-urothelial carcinoma tumor lesions. Thus, applying (THP) photosensitizer fluorescence cystoscopy for early-period bladder cancer diagnosis is safe, effective and practical. It showed a high degree of specificity and a low rate of false positives. It was a convenient visual diagnostic method for the early detection of non-muscular invasive bladder cancer.
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spelling pubmed-55880362017-09-18 Application of pirarubicin photosensitizer fluorescence cystoscopy in early detection of bladder cancer Jiang, Bo Dong, Yang He, Houguang Han, Conghui Oncol Lett Articles The aim of this study was to investigate the value of pirarubicin (THP) photosensitizer fluorescence cystoscopy for the early diagnosis of bladder cancer. From January 2012 to June 2015, 25 patients with painless gross hematuria, were injected with THP 15 min prior to surgery and subsequently underwent fluorescence cystoscopy examination. Locations of tumors were recorded and biopsies were performed (total of 109 biopsies) under white and fluorescence light guidance. Biopsies were conducted at the THP-positive and -negative areas under white light and THP-positive areas under fluorescence light. Positive rate of bladder tumor tissue at the THP-positive areas detected under fluorescence light was 92.86%. The sensitivity and specificity were 100 and 96.15%, respectively. The positive rate of tumor tissue at the THP-positive areas detected under white light was 70.97%. The sensitivity and specificity were 100 and 84.74%, respectively. Fifty biopsies taken at the THP-negative areas under white light were found to be non-urothelial carcinoma tumor lesions. Thus, applying (THP) photosensitizer fluorescence cystoscopy for early-period bladder cancer diagnosis is safe, effective and practical. It showed a high degree of specificity and a low rate of false positives. It was a convenient visual diagnostic method for the early detection of non-muscular invasive bladder cancer. D.A. Spandidos 2017-09 2017-07-12 /pmc/articles/PMC5588036/ /pubmed/28927081 http://dx.doi.org/10.3892/ol.2017.6570 Text en Copyright: © Jiang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Jiang, Bo
Dong, Yang
He, Houguang
Han, Conghui
Application of pirarubicin photosensitizer fluorescence cystoscopy in early detection of bladder cancer
title Application of pirarubicin photosensitizer fluorescence cystoscopy in early detection of bladder cancer
title_full Application of pirarubicin photosensitizer fluorescence cystoscopy in early detection of bladder cancer
title_fullStr Application of pirarubicin photosensitizer fluorescence cystoscopy in early detection of bladder cancer
title_full_unstemmed Application of pirarubicin photosensitizer fluorescence cystoscopy in early detection of bladder cancer
title_short Application of pirarubicin photosensitizer fluorescence cystoscopy in early detection of bladder cancer
title_sort application of pirarubicin photosensitizer fluorescence cystoscopy in early detection of bladder cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588036/
https://www.ncbi.nlm.nih.gov/pubmed/28927081
http://dx.doi.org/10.3892/ol.2017.6570
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