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Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer

This study investigated expression of proliferating cell nuclear antigen (PCNA), proliferation-associated nuclear antigen (Ki-67) and cyclooxygenase-2 (COX-2) in tissues of breast invasive ductal carcinoma, and analyzed the correlations between these indexes and X-ray features in mammography. A tota...

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Autores principales: Qiu, Xiaoming, Mei, Jixin, Yin, Jianjun, Wang, Hong, Wang, Jinqi, Xie, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588100/
https://www.ncbi.nlm.nih.gov/pubmed/28927045
http://dx.doi.org/10.3892/ol.2017.6516
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author Qiu, Xiaoming
Mei, Jixin
Yin, Jianjun
Wang, Hong
Wang, Jinqi
Xie, Ming
author_facet Qiu, Xiaoming
Mei, Jixin
Yin, Jianjun
Wang, Hong
Wang, Jinqi
Xie, Ming
author_sort Qiu, Xiaoming
collection PubMed
description This study investigated expression of proliferating cell nuclear antigen (PCNA), proliferation-associated nuclear antigen (Ki-67) and cyclooxygenase-2 (COX-2) in tissues of breast invasive ductal carcinoma, and analyzed the correlations between these indexes and X-ray features in mammography. A total of 90 patients who were admitted to Huangshi Central Hospital and diagnosed as breast invasive ductal carcinoma from January 2014 to January 2016 were selected. The expression of PCNA, Ki-67 and COX-2 in cancer tissues and cancer-adjacent normal tissues of patients were detected by immunohistochemical staining, and X-ray features in mammography of patients were observed. By using Spearman correlation analysis, the correlations between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer were investigated. As a result, the positive expression rates of PCNA, Ki-67 and COX-2 in cancer tissues of the patient groups were respectively 42.2, 45.6 and 51.1%, which were significantly higher than those in cancer-adjacent normal tissues of the control group (p<0.05). PCNA, Ki-67 and COX-2 expression in cancer tissues of the patient group was associated with clinical staging and lymphatic metastasis (p<0.05), but had no correlation with age and tumor size (p>0.05). PCNA, Ki-67 and COX-2 expression in cancer tissues of the patient group had no correlation with the existence of lumps and localized density-increased shadows (p>0.05), but were associated with manifestations of architectural distortion, calcification as well as skin and nipple depression (p<0.05). Spearman correlation analysis revealed that there was a significantly positive correlation between the expression of PCNA and COX-2 in cancer tissues of the patient group (r=0.676, p<0.05); there was a significantly positive correlation between the expression of Ki-67 and COX-2 (r=0.724, p<0.05); PCNA expression had no obvious correlation with the expression of Ki-67 (p>0.05). In conclusion, PCNA, Ki-67 and COX-2 expression is of great significance in the occurrence, invasion and metastasis of breast invasive ductal carcinoma. There is a strong correlation between PCNA, Ki-67 and COX-2 expression levels and X-ray features in mammography in breast invasive ductal carcinoma. The application of X-ray features in mammography can evaluate the expression levels of PCNA, Ki-67 and COX-2 in tissues of breast invasive ductal carcinoma, thereby prospectively predicting biological behavior of these cancer cells and patient prognosis.
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spelling pubmed-55881002017-09-18 Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer Qiu, Xiaoming Mei, Jixin Yin, Jianjun Wang, Hong Wang, Jinqi Xie, Ming Oncol Lett Articles This study investigated expression of proliferating cell nuclear antigen (PCNA), proliferation-associated nuclear antigen (Ki-67) and cyclooxygenase-2 (COX-2) in tissues of breast invasive ductal carcinoma, and analyzed the correlations between these indexes and X-ray features in mammography. A total of 90 patients who were admitted to Huangshi Central Hospital and diagnosed as breast invasive ductal carcinoma from January 2014 to January 2016 were selected. The expression of PCNA, Ki-67 and COX-2 in cancer tissues and cancer-adjacent normal tissues of patients were detected by immunohistochemical staining, and X-ray features in mammography of patients were observed. By using Spearman correlation analysis, the correlations between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer were investigated. As a result, the positive expression rates of PCNA, Ki-67 and COX-2 in cancer tissues of the patient groups were respectively 42.2, 45.6 and 51.1%, which were significantly higher than those in cancer-adjacent normal tissues of the control group (p<0.05). PCNA, Ki-67 and COX-2 expression in cancer tissues of the patient group was associated with clinical staging and lymphatic metastasis (p<0.05), but had no correlation with age and tumor size (p>0.05). PCNA, Ki-67 and COX-2 expression in cancer tissues of the patient group had no correlation with the existence of lumps and localized density-increased shadows (p>0.05), but were associated with manifestations of architectural distortion, calcification as well as skin and nipple depression (p<0.05). Spearman correlation analysis revealed that there was a significantly positive correlation between the expression of PCNA and COX-2 in cancer tissues of the patient group (r=0.676, p<0.05); there was a significantly positive correlation between the expression of Ki-67 and COX-2 (r=0.724, p<0.05); PCNA expression had no obvious correlation with the expression of Ki-67 (p>0.05). In conclusion, PCNA, Ki-67 and COX-2 expression is of great significance in the occurrence, invasion and metastasis of breast invasive ductal carcinoma. There is a strong correlation between PCNA, Ki-67 and COX-2 expression levels and X-ray features in mammography in breast invasive ductal carcinoma. The application of X-ray features in mammography can evaluate the expression levels of PCNA, Ki-67 and COX-2 in tissues of breast invasive ductal carcinoma, thereby prospectively predicting biological behavior of these cancer cells and patient prognosis. D.A. Spandidos 2017-09 2017-07-04 /pmc/articles/PMC5588100/ /pubmed/28927045 http://dx.doi.org/10.3892/ol.2017.6516 Text en Copyright: © Qiu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Qiu, Xiaoming
Mei, Jixin
Yin, Jianjun
Wang, Hong
Wang, Jinqi
Xie, Ming
Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer
title Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer
title_full Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer
title_fullStr Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer
title_full_unstemmed Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer
title_short Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer
title_sort correlation analysis between expression of pcna, ki-67 and cox-2 and x-ray features in mammography in breast cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588100/
https://www.ncbi.nlm.nih.gov/pubmed/28927045
http://dx.doi.org/10.3892/ol.2017.6516
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