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Prognostic significance of the epithelial-mesenchymal transition factor zinc finger E-box-binding homeobox 2 in esophageal squamous cell carcinoma

Zinc finger E-box-binding homeobox 2 (ZEB2) has been reported to mediate epithelial-mesenchymal transition (EMT) and disease progression in several cancer types. However, the expression of ZEB2 in esophageal squamous cell carcinoma (OSCC) and its association with prognosis remains unclear. In the pr...

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Autores principales: Huo, Xiaodong, Huo, Bin, Wang, Huixing, Zhang, Hongdian, Ma, Zhao, Yang, Mingjian, Wang, Haitao, Yu, Zhentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588115/
https://www.ncbi.nlm.nih.gov/pubmed/28927031
http://dx.doi.org/10.3892/ol.2017.6559
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author Huo, Xiaodong
Huo, Bin
Wang, Huixing
Zhang, Hongdian
Ma, Zhao
Yang, Mingjian
Wang, Haitao
Yu, Zhentao
author_facet Huo, Xiaodong
Huo, Bin
Wang, Huixing
Zhang, Hongdian
Ma, Zhao
Yang, Mingjian
Wang, Haitao
Yu, Zhentao
author_sort Huo, Xiaodong
collection PubMed
description Zinc finger E-box-binding homeobox 2 (ZEB2) has been reported to mediate epithelial-mesenchymal transition (EMT) and disease progression in several cancer types. However, the expression of ZEB2 in esophageal squamous cell carcinoma (OSCC) and its association with prognosis remains unclear. In the present study, a tissue microarray and immunohistochemistry were used to investigate ZEB2 and epithelial (E-)cadherin expression in OSCC tissues (n=218) and peritumoral esophageal tissues (POT; n=60). There was a significantly increased incidence of positive ZEB2 expression in OSCC tissues compared with the expression in POTs (P<0.012). By contrast, the incidence of positive E-cadherin expression in OSCC tissues was significantly decreased compared with the expression in POTs (P<0.004). ZEB2 expression in OSCC was associated with a number of clinicopathological factors, and it was also an independent predictive factor for shorter overall survival time (P<0.001). Overall, ZEB2 may promote OSCC metastasis and is a potential prognostic marker for malignancy.
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spelling pubmed-55881152017-09-18 Prognostic significance of the epithelial-mesenchymal transition factor zinc finger E-box-binding homeobox 2 in esophageal squamous cell carcinoma Huo, Xiaodong Huo, Bin Wang, Huixing Zhang, Hongdian Ma, Zhao Yang, Mingjian Wang, Haitao Yu, Zhentao Oncol Lett Articles Zinc finger E-box-binding homeobox 2 (ZEB2) has been reported to mediate epithelial-mesenchymal transition (EMT) and disease progression in several cancer types. However, the expression of ZEB2 in esophageal squamous cell carcinoma (OSCC) and its association with prognosis remains unclear. In the present study, a tissue microarray and immunohistochemistry were used to investigate ZEB2 and epithelial (E-)cadherin expression in OSCC tissues (n=218) and peritumoral esophageal tissues (POT; n=60). There was a significantly increased incidence of positive ZEB2 expression in OSCC tissues compared with the expression in POTs (P<0.012). By contrast, the incidence of positive E-cadherin expression in OSCC tissues was significantly decreased compared with the expression in POTs (P<0.004). ZEB2 expression in OSCC was associated with a number of clinicopathological factors, and it was also an independent predictive factor for shorter overall survival time (P<0.001). Overall, ZEB2 may promote OSCC metastasis and is a potential prognostic marker for malignancy. D.A. Spandidos 2017-09 2017-07-08 /pmc/articles/PMC5588115/ /pubmed/28927031 http://dx.doi.org/10.3892/ol.2017.6559 Text en Copyright: © Huo et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Huo, Xiaodong
Huo, Bin
Wang, Huixing
Zhang, Hongdian
Ma, Zhao
Yang, Mingjian
Wang, Haitao
Yu, Zhentao
Prognostic significance of the epithelial-mesenchymal transition factor zinc finger E-box-binding homeobox 2 in esophageal squamous cell carcinoma
title Prognostic significance of the epithelial-mesenchymal transition factor zinc finger E-box-binding homeobox 2 in esophageal squamous cell carcinoma
title_full Prognostic significance of the epithelial-mesenchymal transition factor zinc finger E-box-binding homeobox 2 in esophageal squamous cell carcinoma
title_fullStr Prognostic significance of the epithelial-mesenchymal transition factor zinc finger E-box-binding homeobox 2 in esophageal squamous cell carcinoma
title_full_unstemmed Prognostic significance of the epithelial-mesenchymal transition factor zinc finger E-box-binding homeobox 2 in esophageal squamous cell carcinoma
title_short Prognostic significance of the epithelial-mesenchymal transition factor zinc finger E-box-binding homeobox 2 in esophageal squamous cell carcinoma
title_sort prognostic significance of the epithelial-mesenchymal transition factor zinc finger e-box-binding homeobox 2 in esophageal squamous cell carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588115/
https://www.ncbi.nlm.nih.gov/pubmed/28927031
http://dx.doi.org/10.3892/ol.2017.6559
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