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Associations of tumor suppressor SPARCL1 with cancer progression and prognosis

SPARC-like protein 1 (SPARCL1), a member of the family of secreted proteins which is acidic and rich in cysteine, is a potential tumor suppressor gene in most types of tumor. A systemic review and bioinformatics analysis was carried out to determine the associations between SPARCL1 and tumor progres...

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Autores principales: Li, Ting, Liu, Xia, Yang, Antai, Fu, Wenjie, Yin, Fuqiang, Zeng, Xiaoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588123/
https://www.ncbi.nlm.nih.gov/pubmed/28927026
http://dx.doi.org/10.3892/ol.2017.6546
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author Li, Ting
Liu, Xia
Yang, Antai
Fu, Wenjie
Yin, Fuqiang
Zeng, Xiaoyun
author_facet Li, Ting
Liu, Xia
Yang, Antai
Fu, Wenjie
Yin, Fuqiang
Zeng, Xiaoyun
author_sort Li, Ting
collection PubMed
description SPARC-like protein 1 (SPARCL1), a member of the family of secreted proteins which is acidic and rich in cysteine, is a potential tumor suppressor gene in most types of tumor. A systemic review and bioinformatics analysis was carried out to determine the associations between SPARCL1 and tumor progression and clinical factors. Downregulation of SPARCL1, thought to be regulated by epigenetic modifications including DNA methylation, serves important functions in tumor progression and development, with its regulatory functions on cell viability, migration, invasion, cell adhesion and drug resistance. Downregulation of SPARCL1 was markedly associated with a poor overall survival rate of patients with one of ≥7 solid tumors and predicted increased mortality in patients with one of ≥4 distinct tumor types. The present review indicated that SPARCL1 may be a therapeutic target for cancer treatment and a biomarker to determine prognosis.
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spelling pubmed-55881232017-09-18 Associations of tumor suppressor SPARCL1 with cancer progression and prognosis Li, Ting Liu, Xia Yang, Antai Fu, Wenjie Yin, Fuqiang Zeng, Xiaoyun Oncol Lett Review SPARC-like protein 1 (SPARCL1), a member of the family of secreted proteins which is acidic and rich in cysteine, is a potential tumor suppressor gene in most types of tumor. A systemic review and bioinformatics analysis was carried out to determine the associations between SPARCL1 and tumor progression and clinical factors. Downregulation of SPARCL1, thought to be regulated by epigenetic modifications including DNA methylation, serves important functions in tumor progression and development, with its regulatory functions on cell viability, migration, invasion, cell adhesion and drug resistance. Downregulation of SPARCL1 was markedly associated with a poor overall survival rate of patients with one of ≥7 solid tumors and predicted increased mortality in patients with one of ≥4 distinct tumor types. The present review indicated that SPARCL1 may be a therapeutic target for cancer treatment and a biomarker to determine prognosis. D.A. Spandidos 2017-09 2017-07-08 /pmc/articles/PMC5588123/ /pubmed/28927026 http://dx.doi.org/10.3892/ol.2017.6546 Text en Copyright: © Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Li, Ting
Liu, Xia
Yang, Antai
Fu, Wenjie
Yin, Fuqiang
Zeng, Xiaoyun
Associations of tumor suppressor SPARCL1 with cancer progression and prognosis
title Associations of tumor suppressor SPARCL1 with cancer progression and prognosis
title_full Associations of tumor suppressor SPARCL1 with cancer progression and prognosis
title_fullStr Associations of tumor suppressor SPARCL1 with cancer progression and prognosis
title_full_unstemmed Associations of tumor suppressor SPARCL1 with cancer progression and prognosis
title_short Associations of tumor suppressor SPARCL1 with cancer progression and prognosis
title_sort associations of tumor suppressor sparcl1 with cancer progression and prognosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588123/
https://www.ncbi.nlm.nih.gov/pubmed/28927026
http://dx.doi.org/10.3892/ol.2017.6546
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