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In vitro Adhesion of Oral Candida dubliniensis Isolates to Acrylic Denture Surfaces following Brief Exposure to Sub-Cidal Concentrations of Polyenes, Azoles and Chlorhexidine
OBJECTIVES: We aimed to investigate the effect of brief exposure to sub-cidal concentrations of nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate on the adhesion of oral Candida dubliniensis isolates to the surface of acrylic dentures. METHODS: After determining the min...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588188/ https://www.ncbi.nlm.nih.gov/pubmed/25471106 http://dx.doi.org/10.1159/000369019 |
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author | Ellepola, Arjuna N.B. Joseph, Bobby K. Altarakemah, Yacoub Samaranayake, Lakshman P. Anil, Sukumaran Hashem, Mohamed Khan, Zia U. |
author_facet | Ellepola, Arjuna N.B. Joseph, Bobby K. Altarakemah, Yacoub Samaranayake, Lakshman P. Anil, Sukumaran Hashem, Mohamed Khan, Zia U. |
author_sort | Ellepola, Arjuna N.B. |
collection | PubMed |
description | OBJECTIVES: We aimed to investigate the effect of brief exposure to sub-cidal concentrations of nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate on the adhesion of oral Candida dubliniensis isolates to the surface of acrylic dentures. METHODS: After determining the minimum inhibitory concentration of each drug, 20 oral isolates of C. dubliniensis were exposed to sub-cidal concentrations of the drugs for 1 h. The drugs were then removed by dilution, and the adhesion of the isolates to denture acrylic strips was assessed by an in vitro adhesion assay. RESULTS: Compared to the controls, exposure to nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate suppressed the ability of C. dubliniensis isolates to adhere to acrylic denture surfaces with a reduction of 74.68, 74.27, 57.31, 44.57 and 56.53% (p < 0.001 for all drugs), respectively. CONCLUSIONS: Brief exposure to sub-cidal concentrations of anti-mycotics suppressed the adhesion of C. dubliniensis oral isolates to acrylic denture surfaces. |
format | Online Article Text |
id | pubmed-5588188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-55881882017-11-01 In vitro Adhesion of Oral Candida dubliniensis Isolates to Acrylic Denture Surfaces following Brief Exposure to Sub-Cidal Concentrations of Polyenes, Azoles and Chlorhexidine Ellepola, Arjuna N.B. Joseph, Bobby K. Altarakemah, Yacoub Samaranayake, Lakshman P. Anil, Sukumaran Hashem, Mohamed Khan, Zia U. Med Princ Pract Original Paper OBJECTIVES: We aimed to investigate the effect of brief exposure to sub-cidal concentrations of nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate on the adhesion of oral Candida dubliniensis isolates to the surface of acrylic dentures. METHODS: After determining the minimum inhibitory concentration of each drug, 20 oral isolates of C. dubliniensis were exposed to sub-cidal concentrations of the drugs for 1 h. The drugs were then removed by dilution, and the adhesion of the isolates to denture acrylic strips was assessed by an in vitro adhesion assay. RESULTS: Compared to the controls, exposure to nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate suppressed the ability of C. dubliniensis isolates to adhere to acrylic denture surfaces with a reduction of 74.68, 74.27, 57.31, 44.57 and 56.53% (p < 0.001 for all drugs), respectively. CONCLUSIONS: Brief exposure to sub-cidal concentrations of anti-mycotics suppressed the adhesion of C. dubliniensis oral isolates to acrylic denture surfaces. S. Karger AG 2015-01 2014-11-29 /pmc/articles/PMC5588188/ /pubmed/25471106 http://dx.doi.org/10.1159/000369019 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only. |
spellingShingle | Original Paper Ellepola, Arjuna N.B. Joseph, Bobby K. Altarakemah, Yacoub Samaranayake, Lakshman P. Anil, Sukumaran Hashem, Mohamed Khan, Zia U. In vitro Adhesion of Oral Candida dubliniensis Isolates to Acrylic Denture Surfaces following Brief Exposure to Sub-Cidal Concentrations of Polyenes, Azoles and Chlorhexidine |
title | In vitro Adhesion of Oral Candida dubliniensis Isolates to Acrylic Denture Surfaces following Brief Exposure to Sub-Cidal Concentrations of Polyenes, Azoles and Chlorhexidine |
title_full | In vitro Adhesion of Oral Candida dubliniensis Isolates to Acrylic Denture Surfaces following Brief Exposure to Sub-Cidal Concentrations of Polyenes, Azoles and Chlorhexidine |
title_fullStr | In vitro Adhesion of Oral Candida dubliniensis Isolates to Acrylic Denture Surfaces following Brief Exposure to Sub-Cidal Concentrations of Polyenes, Azoles and Chlorhexidine |
title_full_unstemmed | In vitro Adhesion of Oral Candida dubliniensis Isolates to Acrylic Denture Surfaces following Brief Exposure to Sub-Cidal Concentrations of Polyenes, Azoles and Chlorhexidine |
title_short | In vitro Adhesion of Oral Candida dubliniensis Isolates to Acrylic Denture Surfaces following Brief Exposure to Sub-Cidal Concentrations of Polyenes, Azoles and Chlorhexidine |
title_sort | in vitro adhesion of oral candida dubliniensis isolates to acrylic denture surfaces following brief exposure to sub-cidal concentrations of polyenes, azoles and chlorhexidine |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588188/ https://www.ncbi.nlm.nih.gov/pubmed/25471106 http://dx.doi.org/10.1159/000369019 |
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