A Newborn with Teratogenic Effect of Imatinib Mesylate: A Very Rare Case Report

OBJECTIVE: To report a case of teratogenic effect of imatinib mesylate (IM) in a newborn, whose mother was suffering from chronic myelogenous leukemia and was treated with IM for 4 years, including during her pregnancy. CASE PRESENTATION AND INTERVENTION: The newborn was diagnosed with microtia of t...

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Detalles Bibliográficos
Autores principales: Jain, Namita, Sharma, Deepak, Agrawal, Renu, Jain, Adeesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588294/
https://www.ncbi.nlm.nih.gov/pubmed/25896670
http://dx.doi.org/10.1159/000381806
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author Jain, Namita
Sharma, Deepak
Agrawal, Renu
Jain, Adeesh
author_facet Jain, Namita
Sharma, Deepak
Agrawal, Renu
Jain, Adeesh
author_sort Jain, Namita
collection PubMed
description OBJECTIVE: To report a case of teratogenic effect of imatinib mesylate (IM) in a newborn, whose mother was suffering from chronic myelogenous leukemia and was treated with IM for 4 years, including during her pregnancy. CASE PRESENTATION AND INTERVENTION: The newborn was diagnosed with microtia of the right ear, preauricular tag on the left side, absence of right depressor angular oris muscle, and imperforate anus. Infantogram showed dextrocardia, hemivertebrae in the thoracic region and cervical spina bifida occulta. The newborn was operated on for the imperforate anus and was discharged in good condition. CONCLUSION: This case revealed that IM is not safe for the fetus and leads to teratogenicity. Hence, we recommend that pregnant women should not be treated with IM.
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spelling pubmed-55882942017-11-01 A Newborn with Teratogenic Effect of Imatinib Mesylate: A Very Rare Case Report Jain, Namita Sharma, Deepak Agrawal, Renu Jain, Adeesh Med Princ Pract Case Report OBJECTIVE: To report a case of teratogenic effect of imatinib mesylate (IM) in a newborn, whose mother was suffering from chronic myelogenous leukemia and was treated with IM for 4 years, including during her pregnancy. CASE PRESENTATION AND INTERVENTION: The newborn was diagnosed with microtia of the right ear, preauricular tag on the left side, absence of right depressor angular oris muscle, and imperforate anus. Infantogram showed dextrocardia, hemivertebrae in the thoracic region and cervical spina bifida occulta. The newborn was operated on for the imperforate anus and was discharged in good condition. CONCLUSION: This case revealed that IM is not safe for the fetus and leads to teratogenicity. Hence, we recommend that pregnant women should not be treated with IM. S. Karger AG 2015-05 2015-04-17 /pmc/articles/PMC5588294/ /pubmed/25896670 http://dx.doi.org/10.1159/000381806 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Case Report
Jain, Namita
Sharma, Deepak
Agrawal, Renu
Jain, Adeesh
A Newborn with Teratogenic Effect of Imatinib Mesylate: A Very Rare Case Report
title A Newborn with Teratogenic Effect of Imatinib Mesylate: A Very Rare Case Report
title_full A Newborn with Teratogenic Effect of Imatinib Mesylate: A Very Rare Case Report
title_fullStr A Newborn with Teratogenic Effect of Imatinib Mesylate: A Very Rare Case Report
title_full_unstemmed A Newborn with Teratogenic Effect of Imatinib Mesylate: A Very Rare Case Report
title_short A Newborn with Teratogenic Effect of Imatinib Mesylate: A Very Rare Case Report
title_sort newborn with teratogenic effect of imatinib mesylate: a very rare case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588294/
https://www.ncbi.nlm.nih.gov/pubmed/25896670
http://dx.doi.org/10.1159/000381806
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