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Xanthelasma Is Associated with an Increased Amount of Epicardial Adipose Tissue

OBJECTIVE: In the present study, we aimed to compare the amount of epicardial adipose tissue in subjects with and without xanthelasma. SUBJECTS AND METHODS: Fifty-two subjects with xanthelasma and 52 age- and gender-matched control subjects were enrolled in this study. Epicardial adipose tissue was...

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Autores principales: Akyüz, Ali Rıza, Ağaç, Mustafa Tarık, Turan, Turhan, Şahin, Sinan, Kul, Selim, Korkmaz, Levent, Erkuş, Musluhittin Emre, Erkan, Hakan, Çelik, Şükrü
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588332/
https://www.ncbi.nlm.nih.gov/pubmed/26488592
http://dx.doi.org/10.1159/000441846
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author Akyüz, Ali Rıza
Ağaç, Mustafa Tarık
Turan, Turhan
Şahin, Sinan
Kul, Selim
Korkmaz, Levent
Erkuş, Musluhittin Emre
Erkan, Hakan
Çelik, Şükrü
author_facet Akyüz, Ali Rıza
Ağaç, Mustafa Tarık
Turan, Turhan
Şahin, Sinan
Kul, Selim
Korkmaz, Levent
Erkuş, Musluhittin Emre
Erkan, Hakan
Çelik, Şükrü
author_sort Akyüz, Ali Rıza
collection PubMed
description OBJECTIVE: In the present study, we aimed to compare the amount of epicardial adipose tissue in subjects with and without xanthelasma. SUBJECTS AND METHODS: Fifty-two subjects with xanthelasma and 52 age- and gender-matched control subjects were enrolled in this study. Epicardial adipose tissue was assessed by measuring epicardial fat thickness (EFT) with echocardiography. Participants were dichotomized according to median EFT, which was 4 mm. The group with EFT >4 mm was defined as the supramedian group. Body mass index (BMI) was calculated by weight (kilograms) divided by height (meters) squared. Conditional logistic regression analysis was performed to find independent factors associated with supramedian EFT (>4 mm). RESULTS: Subjects with xanthelasma had higher BMI (31.2 ± 5.6 vs. 28.6 ± 5.7, p = 0.01) and higher levels of total cholesterol (216 ± 54 vs. 181 ± 42 mg/dl, p < 0.001), LDL cholesterol (142 ± 45 vs. 115 ± 36 mg/dl, p = 0.003) and triglycerides (median, 154 vs. 101 mg/dl, p = 0.01) than control subjects. EFT was significantly higher in subjects with xanthelasma than in controls (5.04 ± 2.02 vs. 3.81 ± 2.03 mm, p = 0.002). In the conditional logistic regression analysis, the presence of xanthelasma (OR, 3.55; 95% CI, 1.43-8.78, p = 0.006) and lower HDL cholesterol level (OR, 0.96; 95% CI, 0.92-0.99, p = 0.023) were independently associated with supramedian EFT. CONCLUSION: The amount of epicardial adipose tissue found in subjects with xanthelasma was higher than in subjects without xanthelasma. In addition, the presence of xanthelasma was independently associated with supramedian EFT.
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spelling pubmed-55883322017-11-01 Xanthelasma Is Associated with an Increased Amount of Epicardial Adipose Tissue Akyüz, Ali Rıza Ağaç, Mustafa Tarık Turan, Turhan Şahin, Sinan Kul, Selim Korkmaz, Levent Erkuş, Musluhittin Emre Erkan, Hakan Çelik, Şükrü Med Princ Pract Original Paper OBJECTIVE: In the present study, we aimed to compare the amount of epicardial adipose tissue in subjects with and without xanthelasma. SUBJECTS AND METHODS: Fifty-two subjects with xanthelasma and 52 age- and gender-matched control subjects were enrolled in this study. Epicardial adipose tissue was assessed by measuring epicardial fat thickness (EFT) with echocardiography. Participants were dichotomized according to median EFT, which was 4 mm. The group with EFT >4 mm was defined as the supramedian group. Body mass index (BMI) was calculated by weight (kilograms) divided by height (meters) squared. Conditional logistic regression analysis was performed to find independent factors associated with supramedian EFT (>4 mm). RESULTS: Subjects with xanthelasma had higher BMI (31.2 ± 5.6 vs. 28.6 ± 5.7, p = 0.01) and higher levels of total cholesterol (216 ± 54 vs. 181 ± 42 mg/dl, p < 0.001), LDL cholesterol (142 ± 45 vs. 115 ± 36 mg/dl, p = 0.003) and triglycerides (median, 154 vs. 101 mg/dl, p = 0.01) than control subjects. EFT was significantly higher in subjects with xanthelasma than in controls (5.04 ± 2.02 vs. 3.81 ± 2.03 mm, p = 0.002). In the conditional logistic regression analysis, the presence of xanthelasma (OR, 3.55; 95% CI, 1.43-8.78, p = 0.006) and lower HDL cholesterol level (OR, 0.96; 95% CI, 0.92-0.99, p = 0.023) were independently associated with supramedian EFT. CONCLUSION: The amount of epicardial adipose tissue found in subjects with xanthelasma was higher than in subjects without xanthelasma. In addition, the presence of xanthelasma was independently associated with supramedian EFT. S. Karger AG 2016-02 2015-10-21 /pmc/articles/PMC5588332/ /pubmed/26488592 http://dx.doi.org/10.1159/000441846 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Original Paper
Akyüz, Ali Rıza
Ağaç, Mustafa Tarık
Turan, Turhan
Şahin, Sinan
Kul, Selim
Korkmaz, Levent
Erkuş, Musluhittin Emre
Erkan, Hakan
Çelik, Şükrü
Xanthelasma Is Associated with an Increased Amount of Epicardial Adipose Tissue
title Xanthelasma Is Associated with an Increased Amount of Epicardial Adipose Tissue
title_full Xanthelasma Is Associated with an Increased Amount of Epicardial Adipose Tissue
title_fullStr Xanthelasma Is Associated with an Increased Amount of Epicardial Adipose Tissue
title_full_unstemmed Xanthelasma Is Associated with an Increased Amount of Epicardial Adipose Tissue
title_short Xanthelasma Is Associated with an Increased Amount of Epicardial Adipose Tissue
title_sort xanthelasma is associated with an increased amount of epicardial adipose tissue
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588332/
https://www.ncbi.nlm.nih.gov/pubmed/26488592
http://dx.doi.org/10.1159/000441846
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