Mechanochemical N-alkylation of imides

The mechanochemical N-alkylation of imide derivatives was studied. Reactions under solvent-free conditions in a ball mill gave good yields and could be put in place of the classical solution conditions. The method is general and can be applied to various imides and alkyl halides. Phthalimides prepar...

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Detalles Bibliográficos
Autores principales: Briš, Anamarija, Đud, Mateja, Margetić, Davor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588455/
https://www.ncbi.nlm.nih.gov/pubmed/28904618
http://dx.doi.org/10.3762/bjoc.13.169
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author Briš, Anamarija
Đud, Mateja
Margetić, Davor
author_facet Briš, Anamarija
Đud, Mateja
Margetić, Davor
author_sort Briš, Anamarija
collection PubMed
description The mechanochemical N-alkylation of imide derivatives was studied. Reactions under solvent-free conditions in a ball mill gave good yields and could be put in place of the classical solution conditions. The method is general and can be applied to various imides and alkyl halides. Phthalimides prepared under ball milling conditions were used in a mechanochemical Gabriel synthesis of amines by their reaction with 1,2-diaminoethane.
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spelling pubmed-55884552017-09-13 Mechanochemical N-alkylation of imides Briš, Anamarija Đud, Mateja Margetić, Davor Beilstein J Org Chem Full Research Paper The mechanochemical N-alkylation of imide derivatives was studied. Reactions under solvent-free conditions in a ball mill gave good yields and could be put in place of the classical solution conditions. The method is general and can be applied to various imides and alkyl halides. Phthalimides prepared under ball milling conditions were used in a mechanochemical Gabriel synthesis of amines by their reaction with 1,2-diaminoethane. Beilstein-Institut 2017-08-22 /pmc/articles/PMC5588455/ /pubmed/28904618 http://dx.doi.org/10.3762/bjoc.13.169 Text en Copyright © 2017, Briš et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Briš, Anamarija
Đud, Mateja
Margetić, Davor
Mechanochemical N-alkylation of imides
title Mechanochemical N-alkylation of imides
title_full Mechanochemical N-alkylation of imides
title_fullStr Mechanochemical N-alkylation of imides
title_full_unstemmed Mechanochemical N-alkylation of imides
title_short Mechanochemical N-alkylation of imides
title_sort mechanochemical n-alkylation of imides
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588455/
https://www.ncbi.nlm.nih.gov/pubmed/28904618
http://dx.doi.org/10.3762/bjoc.13.169
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AT đudmateja mechanochemicalnalkylationofimides
AT margeticdavor mechanochemicalnalkylationofimides

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