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Priming astrocytes with TNF enhances their susceptibility to Trypanosoma cruzi infection and creates a self-sustaining inflammatory milieu

BACKGROUND: In conditions of immunosuppression, the central nervous sty 5ystem (CNS) is the main target tissue for the reactivation of infection by Trypanosoma cruzi, the causative agent of Chagas disease. In experimental T. cruzi infection, interferon gamma (IFNγ)(+) microglial cells surround astro...

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Detalles Bibliográficos
Autores principales:	Silva, Andrea Alice, Silva, Rafael Rodrigues, Gibaldi, Daniel, Mariante, Rafael Meyer, dos Santos, Jessica Brandão, Pereira, Isabela Resende, Moreira, Otacílio Cruz, Lannes-Vieira, Joseli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588596/ https://www.ncbi.nlm.nih.gov/pubmed/28877735 http://dx.doi.org/10.1186/s12974-017-0952-0

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