Alzheimer’s disease pathological lesions activate the spleen tyrosine kinase

The pathology of Alzheimer’s disease (AD) is characterized by dystrophic neurites (DNs) surrounding extracellular Aβ-plaques, microgliosis, astrogliosis, intraneuronal tau hyperphosphorylation and aggregation. We have previously shown that inhibition of the spleen tyrosine kinase (Syk) lowers Aβ pro...

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Detalles Bibliográficos
Autores principales: Schweig, Jonas Elias, Yao, Hailan, Beaulieu-Abdelahad, David, Ait-Ghezala, Ghania, Mouzon, Benoit, Crawford, Fiona, Mullan, Michael, Paris, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588676/
https://www.ncbi.nlm.nih.gov/pubmed/28877763
http://dx.doi.org/10.1186/s40478-017-0472-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588676/
https://www.ncbi.nlm.nih.gov/pubmed/28877763
http://dx.doi.org/10.1186/s40478-017-0472-2

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