Non-base-contacting residues enable kaleidoscopic evolution of metazoan C2H2 zinc finger DNA binding

BACKGROUND: The C2H2 zinc finger (C2H2-ZF) is the most numerous protein domain in many metazoans, but is not as frequent or diverse in other eukaryotes. The biochemical and evolutionary mechanisms that underlie the diversity of this DNA-binding domain exclusively in metazoans are, however, mostly un...

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Detalles Bibliográficos
Autores principales: Najafabadi, Hamed S., Garton, Michael, Weirauch, Matthew T., Mnaimneh, Sanie, Yang, Ally, Kim, Philip M., Hughes, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588721/
https://www.ncbi.nlm.nih.gov/pubmed/28877740
http://dx.doi.org/10.1186/s13059-017-1287-y

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