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Which symptoms contribute the most to patients’ perception of health in multiple sclerosis?

BACKGROUND: Multiple sclerosis is a polysymptomatic disease. Little is known about relative contributions of the different multiple sclerosis symptoms to self-perception of health. OBJECTIVES: To investigate the relationship between symptom severity in 11 domains affected by multiple sclerosis and s...

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Autores principales: Green, Rivka, Cutter, Gary, Friendly, Michael, Kister, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588807/
https://www.ncbi.nlm.nih.gov/pubmed/28904811
http://dx.doi.org/10.1177/2055217317728301
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author Green, Rivka
Cutter, Gary
Friendly, Michael
Kister, Ilya
author_facet Green, Rivka
Cutter, Gary
Friendly, Michael
Kister, Ilya
author_sort Green, Rivka
collection PubMed
description BACKGROUND: Multiple sclerosis is a polysymptomatic disease. Little is known about relative contributions of the different multiple sclerosis symptoms to self-perception of health. OBJECTIVES: To investigate the relationship between symptom severity in 11 domains affected by multiple sclerosis and self-rated health. METHODS: Multiple sclerosis patients in two multiple sclerosis centers assessed self-rated health with a validated instrument and symptom burden with symptoMScreen, a validated battery of Likert scales for 11 domains commonly affected by multiple sclerosis. Pearson correlations and multivariate linear regressions were used to investigate the relationship between symptoMScreen scores and self-rated health. RESULTS: Among 1865 multiple sclerosis outpatients (68% women, 78% with relapsing–remitting multiple sclerosis, mean age 46.38 ± 12.47 years, disease duration 13.43 ± 10.04 years), average self-rated health score was 2.30 (‘moderate to good’). Symptom burden (composite symptoMScreen score) highly correlated with self-rated health (r = 0.68, P < 0.0001) as did each of the symptoMScreen domain subscores. In regression analysis, pain (t = 7.00), ambulation (t = 6.91), and fatigue (t = 5.85) contributed the highest amount of variance in self-rated health (P < 0.001). CONCLUSIONS: Pain contributed the most to multiple sclerosis outpatients’ perception of health, followed by gait dysfunction and fatigue. These findings suggest that ‘invisible disability’ may be more important to patients’ sense of wellbeing than physical disability, and challenge the notion that physical disability should be the primary outcome measure in multiple sclerosis.
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spelling pubmed-55888072017-09-13 Which symptoms contribute the most to patients’ perception of health in multiple sclerosis? Green, Rivka Cutter, Gary Friendly, Michael Kister, Ilya Mult Scler J Exp Transl Clin Original Research Paper BACKGROUND: Multiple sclerosis is a polysymptomatic disease. Little is known about relative contributions of the different multiple sclerosis symptoms to self-perception of health. OBJECTIVES: To investigate the relationship between symptom severity in 11 domains affected by multiple sclerosis and self-rated health. METHODS: Multiple sclerosis patients in two multiple sclerosis centers assessed self-rated health with a validated instrument and symptom burden with symptoMScreen, a validated battery of Likert scales for 11 domains commonly affected by multiple sclerosis. Pearson correlations and multivariate linear regressions were used to investigate the relationship between symptoMScreen scores and self-rated health. RESULTS: Among 1865 multiple sclerosis outpatients (68% women, 78% with relapsing–remitting multiple sclerosis, mean age 46.38 ± 12.47 years, disease duration 13.43 ± 10.04 years), average self-rated health score was 2.30 (‘moderate to good’). Symptom burden (composite symptoMScreen score) highly correlated with self-rated health (r = 0.68, P < 0.0001) as did each of the symptoMScreen domain subscores. In regression analysis, pain (t = 7.00), ambulation (t = 6.91), and fatigue (t = 5.85) contributed the highest amount of variance in self-rated health (P < 0.001). CONCLUSIONS: Pain contributed the most to multiple sclerosis outpatients’ perception of health, followed by gait dysfunction and fatigue. These findings suggest that ‘invisible disability’ may be more important to patients’ sense of wellbeing than physical disability, and challenge the notion that physical disability should be the primary outcome measure in multiple sclerosis. SAGE Publications 2017-09-05 /pmc/articles/PMC5588807/ /pubmed/28904811 http://dx.doi.org/10.1177/2055217317728301 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Paper
Green, Rivka
Cutter, Gary
Friendly, Michael
Kister, Ilya
Which symptoms contribute the most to patients’ perception of health in multiple sclerosis?
title Which symptoms contribute the most to patients’ perception of health in multiple sclerosis?
title_full Which symptoms contribute the most to patients’ perception of health in multiple sclerosis?
title_fullStr Which symptoms contribute the most to patients’ perception of health in multiple sclerosis?
title_full_unstemmed Which symptoms contribute the most to patients’ perception of health in multiple sclerosis?
title_short Which symptoms contribute the most to patients’ perception of health in multiple sclerosis?
title_sort which symptoms contribute the most to patients’ perception of health in multiple sclerosis?
topic Original Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588807/
https://www.ncbi.nlm.nih.gov/pubmed/28904811
http://dx.doi.org/10.1177/2055217317728301
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