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How transcription circuits explore alternative architectures while maintaining overall circuit output

Transcription regulators bind to cis-regulatory sequences and thereby control the expression of target genes. While transcription regulators and the target genes that they regulate are often deeply conserved across species, the connections between the two change extensively over evolutionary timesca...

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Detalles Bibliográficos
Autores principales: Dalal, Chiraj K., Johnson, Alexander D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588923/
https://www.ncbi.nlm.nih.gov/pubmed/28860157
http://dx.doi.org/10.1101/gad.303362.117
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author Dalal, Chiraj K.
Johnson, Alexander D.
author_facet Dalal, Chiraj K.
Johnson, Alexander D.
author_sort Dalal, Chiraj K.
collection PubMed
description Transcription regulators bind to cis-regulatory sequences and thereby control the expression of target genes. While transcription regulators and the target genes that they regulate are often deeply conserved across species, the connections between the two change extensively over evolutionary timescales. In this review, we discuss case studies where, despite this extensive evolutionary rewiring, the resulting patterns of gene expression are preserved. We also discuss in silico models that reach the same general conclusions and provide additional insights into how this process occurs. Together, these approaches make a strong case that the preservation of gene expression patterns in the wake of extensive rewiring is a general feature of transcription circuit evolution.
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spelling pubmed-55889232018-01-15 How transcription circuits explore alternative architectures while maintaining overall circuit output Dalal, Chiraj K. Johnson, Alexander D. Genes Dev Review Transcription regulators bind to cis-regulatory sequences and thereby control the expression of target genes. While transcription regulators and the target genes that they regulate are often deeply conserved across species, the connections between the two change extensively over evolutionary timescales. In this review, we discuss case studies where, despite this extensive evolutionary rewiring, the resulting patterns of gene expression are preserved. We also discuss in silico models that reach the same general conclusions and provide additional insights into how this process occurs. Together, these approaches make a strong case that the preservation of gene expression patterns in the wake of extensive rewiring is a general feature of transcription circuit evolution. Cold Spring Harbor Laboratory Press 2017-07-15 /pmc/articles/PMC5588923/ /pubmed/28860157 http://dx.doi.org/10.1101/gad.303362.117 Text en © 2017 Dalal and Johnson; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Dalal, Chiraj K.
Johnson, Alexander D.
How transcription circuits explore alternative architectures while maintaining overall circuit output
title How transcription circuits explore alternative architectures while maintaining overall circuit output
title_full How transcription circuits explore alternative architectures while maintaining overall circuit output
title_fullStr How transcription circuits explore alternative architectures while maintaining overall circuit output
title_full_unstemmed How transcription circuits explore alternative architectures while maintaining overall circuit output
title_short How transcription circuits explore alternative architectures while maintaining overall circuit output
title_sort how transcription circuits explore alternative architectures while maintaining overall circuit output
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588923/
https://www.ncbi.nlm.nih.gov/pubmed/28860157
http://dx.doi.org/10.1101/gad.303362.117
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