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Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

Collinear regulation of Hox genes in space and time has been an outstanding question ever since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our understanding of this phenomenon in relation to novel concepts associated with large-scale regulation and chromatin structure d...

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Detalles Bibliográficos
Autores principales: Deschamps, Jacqueline, Duboule, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588924/
https://www.ncbi.nlm.nih.gov/pubmed/28860158
http://dx.doi.org/10.1101/gad.303123.117
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author Deschamps, Jacqueline
Duboule, Denis
author_facet Deschamps, Jacqueline
Duboule, Denis
author_sort Deschamps, Jacqueline
collection PubMed
description Collinear regulation of Hox genes in space and time has been an outstanding question ever since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our understanding of this phenomenon in relation to novel concepts associated with large-scale regulation and chromatin structure during the development of both axial and limb patterns. We further discuss how this sequential transcriptional activation marks embryonic stem cell-like axial progenitors in mammals and, consequently, how a temporal genetic system is further translated into spatial coordinates via the fate of these progenitors. In this context, we argue the benefit and necessity of implementing this unique mechanism as well as the difficulty in evolving an alternative strategy to deliver this critical positional information.
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spelling pubmed-55889242017-09-21 Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock Deschamps, Jacqueline Duboule, Denis Genes Dev Review Collinear regulation of Hox genes in space and time has been an outstanding question ever since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our understanding of this phenomenon in relation to novel concepts associated with large-scale regulation and chromatin structure during the development of both axial and limb patterns. We further discuss how this sequential transcriptional activation marks embryonic stem cell-like axial progenitors in mammals and, consequently, how a temporal genetic system is further translated into spatial coordinates via the fate of these progenitors. In this context, we argue the benefit and necessity of implementing this unique mechanism as well as the difficulty in evolving an alternative strategy to deliver this critical positional information. Cold Spring Harbor Laboratory Press 2017-07-15 /pmc/articles/PMC5588924/ /pubmed/28860158 http://dx.doi.org/10.1101/gad.303123.117 Text en © 2017 Deschamps and Duboule; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by/4.0/ This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Deschamps, Jacqueline
Duboule, Denis
Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock
title Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock
title_full Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock
title_fullStr Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock
title_full_unstemmed Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock
title_short Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock
title_sort embryonic timing, axial stem cells, chromatin dynamics, and the hox clock
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588924/
https://www.ncbi.nlm.nih.gov/pubmed/28860158
http://dx.doi.org/10.1101/gad.303123.117
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