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Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock
Collinear regulation of Hox genes in space and time has been an outstanding question ever since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our understanding of this phenomenon in relation to novel concepts associated with large-scale regulation and chromatin structure d...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588924/ https://www.ncbi.nlm.nih.gov/pubmed/28860158 http://dx.doi.org/10.1101/gad.303123.117 |
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author | Deschamps, Jacqueline Duboule, Denis |
author_facet | Deschamps, Jacqueline Duboule, Denis |
author_sort | Deschamps, Jacqueline |
collection | PubMed |
description | Collinear regulation of Hox genes in space and time has been an outstanding question ever since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our understanding of this phenomenon in relation to novel concepts associated with large-scale regulation and chromatin structure during the development of both axial and limb patterns. We further discuss how this sequential transcriptional activation marks embryonic stem cell-like axial progenitors in mammals and, consequently, how a temporal genetic system is further translated into spatial coordinates via the fate of these progenitors. In this context, we argue the benefit and necessity of implementing this unique mechanism as well as the difficulty in evolving an alternative strategy to deliver this critical positional information. |
format | Online Article Text |
id | pubmed-5588924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55889242017-09-21 Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock Deschamps, Jacqueline Duboule, Denis Genes Dev Review Collinear regulation of Hox genes in space and time has been an outstanding question ever since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our understanding of this phenomenon in relation to novel concepts associated with large-scale regulation and chromatin structure during the development of both axial and limb patterns. We further discuss how this sequential transcriptional activation marks embryonic stem cell-like axial progenitors in mammals and, consequently, how a temporal genetic system is further translated into spatial coordinates via the fate of these progenitors. In this context, we argue the benefit and necessity of implementing this unique mechanism as well as the difficulty in evolving an alternative strategy to deliver this critical positional information. Cold Spring Harbor Laboratory Press 2017-07-15 /pmc/articles/PMC5588924/ /pubmed/28860158 http://dx.doi.org/10.1101/gad.303123.117 Text en © 2017 Deschamps and Duboule; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by/4.0/ This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Deschamps, Jacqueline Duboule, Denis Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock |
title | Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock |
title_full | Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock |
title_fullStr | Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock |
title_full_unstemmed | Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock |
title_short | Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock |
title_sort | embryonic timing, axial stem cells, chromatin dynamics, and the hox clock |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588924/ https://www.ncbi.nlm.nih.gov/pubmed/28860158 http://dx.doi.org/10.1101/gad.303123.117 |
work_keys_str_mv | AT deschampsjacqueline embryonictimingaxialstemcellschromatindynamicsandthehoxclock AT dubouledenis embryonictimingaxialstemcellschromatindynamicsandthehoxclock |