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Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol
INTRODUCTION: The acceptability and efficacy of existing ready-to-use supplementary and therapeutic foods has been low in Cambodia, thus limiting success in preventing and treating malnutrition among Cambodian children. In that context, UNICEF and IRD have developed a locally produced, multiple micr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588973/ https://www.ncbi.nlm.nih.gov/pubmed/28882910 http://dx.doi.org/10.1136/bmjopen-2017-015958 |
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author | Borg, Bindi Mihrshahi, Seema Griffin, Mark Chamnan, Chhoun Laillou, Arnaud Wieringa, Frank T |
author_facet | Borg, Bindi Mihrshahi, Seema Griffin, Mark Chamnan, Chhoun Laillou, Arnaud Wieringa, Frank T |
author_sort | Borg, Bindi |
collection | PubMed |
description | INTRODUCTION: The acceptability and efficacy of existing ready-to-use supplementary and therapeutic foods has been low in Cambodia, thus limiting success in preventing and treating malnutrition among Cambodian children. In that context, UNICEF and IRD have developed a locally produced, multiple micronutrient fortified lipid-based nutrient supplement. This food is innovative, in that it uses fish instead of milk as the animal source food. Very few supplementary foods have non-milk animal source foods, and in addition they have not been widely tested. This trial will assess the novel food’s acceptability to children and caregivers. METHODS AND ANALYSIS: This is a cluster-randomised, incomplete block, 4×4 crossover design with no blinding. It will take place in four sites in a community setting in periurban Phnom Penh. Healthy children aged 9–23 months (n=100) will eat each of four foods for 3 days at a time. The amount they consume will be measured, and at the end of each 3-day set, caregivers will assess how well their child liked the food. After 12 days, caregivers themselves will do a sensory test of the 4 foods and will rank them in terms of preference. ETHICS AND DISSEMINATION: Ethical clearance was received from the University of Queensland Medical Research Ethics Committee (2014001070) and from Cambodia’s National Ethics Committee for Health Research (03/8 NECHR). REGISTRATION: ClinicalTrials.gov, identifier: LNS-CAMB-INFANTS; NCT02257437. Pre-results. |
format | Online Article Text |
id | pubmed-5588973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-55889732017-09-14 Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol Borg, Bindi Mihrshahi, Seema Griffin, Mark Chamnan, Chhoun Laillou, Arnaud Wieringa, Frank T BMJ Open Global Health INTRODUCTION: The acceptability and efficacy of existing ready-to-use supplementary and therapeutic foods has been low in Cambodia, thus limiting success in preventing and treating malnutrition among Cambodian children. In that context, UNICEF and IRD have developed a locally produced, multiple micronutrient fortified lipid-based nutrient supplement. This food is innovative, in that it uses fish instead of milk as the animal source food. Very few supplementary foods have non-milk animal source foods, and in addition they have not been widely tested. This trial will assess the novel food’s acceptability to children and caregivers. METHODS AND ANALYSIS: This is a cluster-randomised, incomplete block, 4×4 crossover design with no blinding. It will take place in four sites in a community setting in periurban Phnom Penh. Healthy children aged 9–23 months (n=100) will eat each of four foods for 3 days at a time. The amount they consume will be measured, and at the end of each 3-day set, caregivers will assess how well their child liked the food. After 12 days, caregivers themselves will do a sensory test of the 4 foods and will rank them in terms of preference. ETHICS AND DISSEMINATION: Ethical clearance was received from the University of Queensland Medical Research Ethics Committee (2014001070) and from Cambodia’s National Ethics Committee for Health Research (03/8 NECHR). REGISTRATION: ClinicalTrials.gov, identifier: LNS-CAMB-INFANTS; NCT02257437. Pre-results. BMJ Publishing Group 2017-09-06 /pmc/articles/PMC5588973/ /pubmed/28882910 http://dx.doi.org/10.1136/bmjopen-2017-015958 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Global Health Borg, Bindi Mihrshahi, Seema Griffin, Mark Chamnan, Chhoun Laillou, Arnaud Wieringa, Frank T Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol |
title | Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol |
title_full | Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol |
title_fullStr | Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol |
title_full_unstemmed | Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol |
title_short | Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol |
title_sort | crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (lns) for children under 2 years in cambodia: a study protocol |
topic | Global Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588973/ https://www.ncbi.nlm.nih.gov/pubmed/28882910 http://dx.doi.org/10.1136/bmjopen-2017-015958 |
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