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Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis
OBJECTIVES: Heterozygous familial hypercholesterolaemia (FH) confers a significant risk for premature cardiovascular disease (CVD). However, the estimated prevalence of FH varies substantially among studies. We aimed to provide a summary estimate of FH prevalence in the general population and assess...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588988/ https://www.ncbi.nlm.nih.gov/pubmed/28864697 http://dx.doi.org/10.1136/bmjopen-2017-016461 |
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author | Akioyamen, Leo E Genest, Jacques Shan, Shubham D Reel, Rachel L Albaum, Jordan M Chu, Anna Tu, Jack V |
author_facet | Akioyamen, Leo E Genest, Jacques Shan, Shubham D Reel, Rachel L Albaum, Jordan M Chu, Anna Tu, Jack V |
author_sort | Akioyamen, Leo E |
collection | PubMed |
description | OBJECTIVES: Heterozygous familial hypercholesterolaemia (FH) confers a significant risk for premature cardiovascular disease (CVD). However, the estimated prevalence of FH varies substantially among studies. We aimed to provide a summary estimate of FH prevalence in the general population and assess variations in frequency across different sociodemographic characteristics. SETTING, PARTICIPANTS AND OUTCOME MEASURES: We searched MEDLINE, EMBASE, Global Health, the Cochrane Library, PsycINFO and PubMed for peer-reviewed literature using validated strategies. Results were limited to studies published in English between January 1990 and January 2017. Studies were eligible if they determined FH prevalence using clinical criteria or DNA-based analyses. We determined a pooled point prevalence of FH in adults and children and assessed the variation of the pooled frequency by age, sex, geographical location, diagnostic method, study quality and year of publication. Estimates were pooled using random-effects meta-analysis. Differences by study-level characteristics were investigated through subgroups, meta-regression and sensitivity analyses. RESULTS: The pooled prevalence of FH from 19 studies including 2 458 456 unique individuals was 0.40% (95% CI 0.29% to 0.52%) which corresponds to a frequency of 1 in 250 individuals. FH prevalence was found to vary by age and geographical location but not by any other covariates. Results were consistent in sensitivity analyses. CONCLUSIONS: Our systematic review suggests that FH is a common disorder, affecting 1 in 250 individuals. These findings underscore the need for early detection and management to decrease CVD risk. |
format | Online Article Text |
id | pubmed-5588988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-55889882017-09-14 Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis Akioyamen, Leo E Genest, Jacques Shan, Shubham D Reel, Rachel L Albaum, Jordan M Chu, Anna Tu, Jack V BMJ Open Cardiovascular Medicine OBJECTIVES: Heterozygous familial hypercholesterolaemia (FH) confers a significant risk for premature cardiovascular disease (CVD). However, the estimated prevalence of FH varies substantially among studies. We aimed to provide a summary estimate of FH prevalence in the general population and assess variations in frequency across different sociodemographic characteristics. SETTING, PARTICIPANTS AND OUTCOME MEASURES: We searched MEDLINE, EMBASE, Global Health, the Cochrane Library, PsycINFO and PubMed for peer-reviewed literature using validated strategies. Results were limited to studies published in English between January 1990 and January 2017. Studies were eligible if they determined FH prevalence using clinical criteria or DNA-based analyses. We determined a pooled point prevalence of FH in adults and children and assessed the variation of the pooled frequency by age, sex, geographical location, diagnostic method, study quality and year of publication. Estimates were pooled using random-effects meta-analysis. Differences by study-level characteristics were investigated through subgroups, meta-regression and sensitivity analyses. RESULTS: The pooled prevalence of FH from 19 studies including 2 458 456 unique individuals was 0.40% (95% CI 0.29% to 0.52%) which corresponds to a frequency of 1 in 250 individuals. FH prevalence was found to vary by age and geographical location but not by any other covariates. Results were consistent in sensitivity analyses. CONCLUSIONS: Our systematic review suggests that FH is a common disorder, affecting 1 in 250 individuals. These findings underscore the need for early detection and management to decrease CVD risk. BMJ Publishing Group 2017-09-01 /pmc/articles/PMC5588988/ /pubmed/28864697 http://dx.doi.org/10.1136/bmjopen-2017-016461 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Cardiovascular Medicine Akioyamen, Leo E Genest, Jacques Shan, Shubham D Reel, Rachel L Albaum, Jordan M Chu, Anna Tu, Jack V Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis |
title | Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis |
title_full | Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis |
title_fullStr | Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis |
title_full_unstemmed | Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis |
title_short | Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis |
title_sort | estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588988/ https://www.ncbi.nlm.nih.gov/pubmed/28864697 http://dx.doi.org/10.1136/bmjopen-2017-016461 |
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