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Gemcitabine-induced chronic systemic capillary leak syndrome

A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the differential diagnos...

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Detalles Bibliográficos
Autores principales: Bajwa, Ravneet, Starr, Jason, Daily, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589048/
https://www.ncbi.nlm.nih.gov/pubmed/28855215
http://dx.doi.org/10.1136/bcr-2017-221068
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author Bajwa, Ravneet
Starr, Jason
Daily, Karen
author_facet Bajwa, Ravneet
Starr, Jason
Daily, Karen
author_sort Bajwa, Ravneet
collection PubMed
description A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the differential diagnosis. Vascular endothelial growth factor levels were elevated at 707 pg/mL (reference range: 9–86 pg/mL). Corticosteroids were initiated, resulting in complete resolution of symptoms and hypotension. The patient suffered relapse of symptoms on discontinuation of steroids, further supporting chronic capillary leak syndrome.
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spelling pubmed-55890482017-09-14 Gemcitabine-induced chronic systemic capillary leak syndrome Bajwa, Ravneet Starr, Jason Daily, Karen BMJ Case Rep Article A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the differential diagnosis. Vascular endothelial growth factor levels were elevated at 707 pg/mL (reference range: 9–86 pg/mL). Corticosteroids were initiated, resulting in complete resolution of symptoms and hypotension. The patient suffered relapse of symptoms on discontinuation of steroids, further supporting chronic capillary leak syndrome. BMJ Publishing Group 2017-08-30 /pmc/articles/PMC5589048/ /pubmed/28855215 http://dx.doi.org/10.1136/bcr-2017-221068 Text en © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Article
Bajwa, Ravneet
Starr, Jason
Daily, Karen
Gemcitabine-induced chronic systemic capillary leak syndrome
title Gemcitabine-induced chronic systemic capillary leak syndrome
title_full Gemcitabine-induced chronic systemic capillary leak syndrome
title_fullStr Gemcitabine-induced chronic systemic capillary leak syndrome
title_full_unstemmed Gemcitabine-induced chronic systemic capillary leak syndrome
title_short Gemcitabine-induced chronic systemic capillary leak syndrome
title_sort gemcitabine-induced chronic systemic capillary leak syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589048/
https://www.ncbi.nlm.nih.gov/pubmed/28855215
http://dx.doi.org/10.1136/bcr-2017-221068
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