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Gemcitabine-induced chronic systemic capillary leak syndrome
A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the differential diagnos...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589048/ https://www.ncbi.nlm.nih.gov/pubmed/28855215 http://dx.doi.org/10.1136/bcr-2017-221068 |
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author | Bajwa, Ravneet Starr, Jason Daily, Karen |
author_facet | Bajwa, Ravneet Starr, Jason Daily, Karen |
author_sort | Bajwa, Ravneet |
collection | PubMed |
description | A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the differential diagnosis. Vascular endothelial growth factor levels were elevated at 707 pg/mL (reference range: 9–86 pg/mL). Corticosteroids were initiated, resulting in complete resolution of symptoms and hypotension. The patient suffered relapse of symptoms on discontinuation of steroids, further supporting chronic capillary leak syndrome. |
format | Online Article Text |
id | pubmed-5589048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-55890482017-09-14 Gemcitabine-induced chronic systemic capillary leak syndrome Bajwa, Ravneet Starr, Jason Daily, Karen BMJ Case Rep Article A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the differential diagnosis. Vascular endothelial growth factor levels were elevated at 707 pg/mL (reference range: 9–86 pg/mL). Corticosteroids were initiated, resulting in complete resolution of symptoms and hypotension. The patient suffered relapse of symptoms on discontinuation of steroids, further supporting chronic capillary leak syndrome. BMJ Publishing Group 2017-08-30 /pmc/articles/PMC5589048/ /pubmed/28855215 http://dx.doi.org/10.1136/bcr-2017-221068 Text en © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Article Bajwa, Ravneet Starr, Jason Daily, Karen Gemcitabine-induced chronic systemic capillary leak syndrome |
title | Gemcitabine-induced chronic systemic capillary leak syndrome |
title_full | Gemcitabine-induced chronic systemic capillary leak syndrome |
title_fullStr | Gemcitabine-induced chronic systemic capillary leak syndrome |
title_full_unstemmed | Gemcitabine-induced chronic systemic capillary leak syndrome |
title_short | Gemcitabine-induced chronic systemic capillary leak syndrome |
title_sort | gemcitabine-induced chronic systemic capillary leak syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589048/ https://www.ncbi.nlm.nih.gov/pubmed/28855215 http://dx.doi.org/10.1136/bcr-2017-221068 |
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