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RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

RNase H1-dependent antisense oligonucleotides (ASOs) are active in reducing levels of both cytoplasmic mRNAs and nuclear retained RNAs. Although ASO activity in the nucleus has been well demonstrated, the cytoplasmic activity of ASOs is less clear. Using kinetic and subcellular fractionation studies...

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Detalles Bibliográficos
Autores principales:	Liang, Xue-Hai, Sun, Hong, Nichols, Joshua G., Crooke, Stanley T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589097/ https://www.ncbi.nlm.nih.gov/pubmed/28663102 http://dx.doi.org/10.1016/j.ymthe.2017.06.002

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