Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis

Despite aggressive antibiotic therapy, bronchopulmonary colonization by Pseudomonas aeruginosa causes persistent morbidity and mortality in cystic fibrosis (CF). Chronic P. aeruginosa infection in the CF lung is associated with structured, antibiotic-tolerant bacterial aggregates known as biofilms....

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Detalles Bibliográficos
Autores principales: Howlin, Robert P., Cathie, Katrina, Hall-Stoodley, Luanne, Cornelius, Victoria, Duignan, Caroline, Allan, Raymond N., Fernandez, Bernadette O., Barraud, Nicolas, Bruce, Ken D., Jefferies, Johanna, Kelso, Michael, Kjelleberg, Staffan, Rice, Scott A., Rogers, Geraint B., Pink, Sandra, Smith, Caroline, Sukhtankar, Priya S., Salib, Rami, Legg, Julian, Carroll, Mary, Daniels, Thomas, Feelisch, Martin, Stoodley, Paul, Clarke, Stuart C., Connett, Gary, Faust, Saul N., Webb, Jeremy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589160/
https://www.ncbi.nlm.nih.gov/pubmed/28750737
http://dx.doi.org/10.1016/j.ymthe.2017.06.021

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