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Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy

The early diagnosis of diabetic peripheral neuropathy (DPN) is challenging. Sudomotor dysfunction is one of the earliest detectable abnormalities in DPN. The present study aimed to determine the diagnostic performance of the electrochemical skin conductance (ESC) test in detecting early DPN, compare...

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Autores principales: Goel, Amit, Shivaprasad, Channabasappa, Kolly, Anish, Sarathi H. A., Vijaya, Atluri, Sridevi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589170/
https://www.ncbi.nlm.nih.gov/pubmed/28880907
http://dx.doi.org/10.1371/journal.pone.0183973
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author Goel, Amit
Shivaprasad, Channabasappa
Kolly, Anish
Sarathi H. A., Vijaya
Atluri, Sridevi
author_facet Goel, Amit
Shivaprasad, Channabasappa
Kolly, Anish
Sarathi H. A., Vijaya
Atluri, Sridevi
author_sort Goel, Amit
collection PubMed
description The early diagnosis of diabetic peripheral neuropathy (DPN) is challenging. Sudomotor dysfunction is one of the earliest detectable abnormalities in DPN. The present study aimed to determine the diagnostic performance of the electrochemical skin conductance (ESC) test in detecting early DPN, compared with the vibration perception threshold (VPT) test and diabetic neuropathy symptom (DNS) score, using the modified neuropathy disability score (NDS) as the reference standard. Five hundred and twenty-three patients with type 2 diabetes underwent an NDS-based clinical assessment for neuropathy. Participants were classified into the DPN and non-DPN groups based on the NDS (≥ 6). Both groups were evaluated further using the DNS, and VPT and ESC testing. A receiver-operator characteristic (ROC) curve analysis was performed to compare the efficacy of ESC measurements with those of DNS and VPT testing in detecting DPN. The DPN group (n = 110, 21%) had significantly higher HbA1c levels and longer diabetes durations compared with the non-DPN group (n = 413). The sensitivity of feet ESC < 60 μS, VPT testing, and DNS in detecting DPN were 85%, 72%, and 52%, respectively. The specificity of feet ESC, VPT, and DNS in detecting DPN were 85%, 90% and 60% respectively. The areas under the curves of the ROC plots for feet ESC, VPT testing, and DNS were 0.88, 0.84, and 0.6, respectively. A significant inverse linear relationship was noted between VPT and feet ESC (r = -0.45, p = <0.0001). The odds ratios for having DPN, based on the mean feet ESC testing < 60 μS, VPT testing > 15 V, and DNS ≥ 1, were 16.4, 10.9 and 1.8, respectively. ESC measurement is an objective and sensitive technique for the early detection of DPN. Feet ESC measurement was superior to VPT testing for identifying patients with early DPN.
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spelling pubmed-55891702017-09-15 Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy Goel, Amit Shivaprasad, Channabasappa Kolly, Anish Sarathi H. A., Vijaya Atluri, Sridevi PLoS One Research Article The early diagnosis of diabetic peripheral neuropathy (DPN) is challenging. Sudomotor dysfunction is one of the earliest detectable abnormalities in DPN. The present study aimed to determine the diagnostic performance of the electrochemical skin conductance (ESC) test in detecting early DPN, compared with the vibration perception threshold (VPT) test and diabetic neuropathy symptom (DNS) score, using the modified neuropathy disability score (NDS) as the reference standard. Five hundred and twenty-three patients with type 2 diabetes underwent an NDS-based clinical assessment for neuropathy. Participants were classified into the DPN and non-DPN groups based on the NDS (≥ 6). Both groups were evaluated further using the DNS, and VPT and ESC testing. A receiver-operator characteristic (ROC) curve analysis was performed to compare the efficacy of ESC measurements with those of DNS and VPT testing in detecting DPN. The DPN group (n = 110, 21%) had significantly higher HbA1c levels and longer diabetes durations compared with the non-DPN group (n = 413). The sensitivity of feet ESC < 60 μS, VPT testing, and DNS in detecting DPN were 85%, 72%, and 52%, respectively. The specificity of feet ESC, VPT, and DNS in detecting DPN were 85%, 90% and 60% respectively. The areas under the curves of the ROC plots for feet ESC, VPT testing, and DNS were 0.88, 0.84, and 0.6, respectively. A significant inverse linear relationship was noted between VPT and feet ESC (r = -0.45, p = <0.0001). The odds ratios for having DPN, based on the mean feet ESC testing < 60 μS, VPT testing > 15 V, and DNS ≥ 1, were 16.4, 10.9 and 1.8, respectively. ESC measurement is an objective and sensitive technique for the early detection of DPN. Feet ESC measurement was superior to VPT testing for identifying patients with early DPN. Public Library of Science 2017-09-07 /pmc/articles/PMC5589170/ /pubmed/28880907 http://dx.doi.org/10.1371/journal.pone.0183973 Text en © 2017 Goel et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Goel, Amit
Shivaprasad, Channabasappa
Kolly, Anish
Sarathi H. A., Vijaya
Atluri, Sridevi
Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy
title Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy
title_full Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy
title_fullStr Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy
title_full_unstemmed Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy
title_short Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy
title_sort comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589170/
https://www.ncbi.nlm.nih.gov/pubmed/28880907
http://dx.doi.org/10.1371/journal.pone.0183973
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