The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits

There is interest in pharmacologic preconditioning for end-organ protection by targeting the HIF system. This can be accomplished by inhibition of prolyl 4-hydroxylase (PHD). GSK360A is an orally active PHD inhibitor that has been previously shown to protect the failing heart. We hypothesized that P...

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Detalles Bibliográficos
Autores principales: Zhou, Jin, Li, Jie, Rosenbaum, Daniel M., Zhuang, Jian, Poon, Carrie, Qin, Pu, Rivera, Katrina, Lepore, John, Willette, Robert N., Hu, Erding, Barone, Frank C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589177/
https://www.ncbi.nlm.nih.gov/pubmed/28880966
http://dx.doi.org/10.1371/journal.pone.0184049

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