MDM2 antagonists synergize with PI3K/mTOR inhibition in well-differentiated/dedifferentiated liposarcomas

BACKGROUND: Well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) are characterized by a consistent amplification of the MDM2 gene. The PI3K/AKT/mTOR pathway has been suggested to play also an important role in their tumorigenesis. Our goal was to determine whether combined MDM2 and PI3K/AK...

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Detalles Bibliográficos
Autores principales: Laroche, Audrey, Chaire, Vanessa, Algeo, Marie-Paule, Karanian, Marie, Fourneaux, Benjamin, Italiano, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589555/
https://www.ncbi.nlm.nih.gov/pubmed/28903316
http://dx.doi.org/10.18632/oncotarget.16345

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