Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness

Obscurins are a family of RhoGEF-containing proteins with tumor and metastasis suppressing roles in breast epithelium. Downregulation of giant obscurins in normal breast epithelial cells leads to reduced levels of active RhoA and of its downstream effectors. Herein, we elucidate how depletion of gia...

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Detalles Bibliográficos
Autores principales: Stroka, Kimberly M., Wong, Bin Sheng, Shriver, Marey, Phillip, Jude M., Wirtz, Denis, Kontrogianni-Konstantopoulos, Aikaterini, Konstantopoulos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589558/
https://www.ncbi.nlm.nih.gov/pubmed/28903319
http://dx.doi.org/10.18632/oncotarget.10997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589558/
https://www.ncbi.nlm.nih.gov/pubmed/28903319
http://dx.doi.org/10.18632/oncotarget.10997

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