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CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner

JAK2 activation is the driver mechanism in BCR-ABL-negative myeloproliferative neoplasms (MPN). These diseases are characterized by an abnormal retention of hematopoietic stem cells within the bone marrow microenvironment and their increased trafficking to extramedullary sites. The CXCL12/CXCR4 axis...

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Detalles Bibliográficos
Autores principales:	Abdelouahab, Hadjer, Zhang, Yanyan, Wittner, Monika, Oishi, Shinya, Fujii, Nobutaka, Besancenot, Rodolphe, Plo, Isabelle, Ribrag, Vincent, Solary, Eric, Vainchenker, William, Barosi, Giovanni, Louache, Fawzia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589564/ https://www.ncbi.nlm.nih.gov/pubmed/28903325 http://dx.doi.org/10.18632/oncotarget.10789

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