Cargando…

Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines in vitro and AKT-driven hepatocarcinogenesis in mice

Upregulation of the heat shock transcription factor 1 (HSF1) has been described as a frequent event in many cancer types, but its oncogenic role in hepatocellular carcinoma (HCC) remains poorly delineated. In the present study, we assessed the function(s) of HSF1 in hepatocarcinogenesis via in vitro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cigliano, Antonio, Wang, Chunmei, Pilo, Maria G., Szydlowska, Marta, Brozzetti, Stefania, Latte, Gavinella, Pes, Giovanni M., Pascale, Rosa M., Seddaiu, Maria A., Vidili, Gianpaolo, Ribback, Silvia, Dombrowski, Frank, Evert, Matthias, Chen, Xin, Calvisi, Diego F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589569/ https://www.ncbi.nlm.nih.gov/pubmed/28903330 http://dx.doi.org/10.18632/oncotarget.16927

Ejemplares similares

Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis
por: Cigliano, Antonio, et al.
Publicado: (2017)

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice
por: Hu, Junjie, et al.
Publicado: (2016)

Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value
por: Evert, M, et al.
Publicado: (2013)

Alterations of methionine metabolism in hepatocarcinogenesis: the emergent role of glycine N-methyltransferase in liver injury
por: Simile, Maria M., et al.
Publicado: (2018)

Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: Implications for the treatment of human liver cancer
por: Wang, Chunmei, et al.
Publicado: (2013)

The Epidermal Growth Factor Receptor (EGFR) Inhibitor Gefitinib Reduces but Does Not Prevent Tumorigenesis in Chemical and Hormonal Induced Hepatocarcinogenesis Rat Models
por: Ribback, Silvia, et al.
Publicado: (2016)

SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice
por: Li, Lei, et al.
Publicado: (2013)

Inhibition of MELK Protooncogene as an Innovative Treatment for Intrahepatic Cholangiocarcinoma
por: Cigliano, Antonio, et al.
Publicado: (2019)

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
por: Che, Li, et al.
Publicado: (2020)

PI3K/AKT/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men
por: Ribback, Silvia, et al.
Publicado: (2015)

Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis
por: Jia, Jiaoyuan, et al.
Publicado: (2020)

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease
por: Simile, Maria M., et al.
Publicado: (2016)

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice
por: Delogu, Salvatore, et al.
Publicado: (2014)

Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans
por: Che, L, et al.
Publicado: (2016)

Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis
por: Wang, Haichuan, et al.
Publicado: (2020)

Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase
por: Simile, Maria M., et al.
Publicado: (2021)

Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway
por: Xu, Zhong, et al.
Publicado: (2018)

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease
por: Cigliano, Antonio, et al.
Publicado: (2022)

Correction: The Hippo pathway efector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease
por: Cigliano, Antonio, et al.
Publicado: (2023)

RASSF1A independence and early galectin‐1 upregulation in PIK3CA‐induced hepatocarcinogenesis: new therapeutic venues
por: Scheiter, Alexander, et al.
Publicado: (2021)

Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver
por: Li, Xiaolei, et al.
Publicado: (2015)

Functional role of SGK3 in PI3K/Pten driven liver tumor development
por: Cao, Hui, et al.
Publicado: (2019)

Early Subcellular Hepatocellular Alterations in Mice Post Hydrodynamic Transfection: An Explorative Study
por: Yasser, Mohd, et al.
Publicado: (2023)

Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis
por: Klemm, Sophie, et al.
Publicado: (2023)

Hepatocellular glycogenotic foci after combined intraportal pancreatic islet transplantation and knockout of the carbohydrate responsive element binding protein in diabetic mice
por: Ribback, Silvia, et al.
Publicado: (2017)

Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development
por: Liu, Pin, et al.
Publicado: (2017)

Oncogene-dependent function of BRG1 in hepatocarcinogenesis
por: Wang, Pan, et al.
Publicado: (2020)

Inverse Association between Glucose-6-Phosphate Dehydrogenase Deficiency and Hepatocellular Carcinoma
por: Dore, Maria Pina, et al.
Publicado: (2018)

Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism
por: Metzendorf, Christoph, et al.
Publicado: (2020)

Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model
por: Dong, Mingjie, et al.
Publicado: (2018)

MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes
por: Simile, Maria M., et al.
Publicado: (2019)

Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma
por: Che, Li, et al.
Publicado: (2019)

Corrigendum: Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma
por: Che, Li, et al.
Publicado: (2022)

Experimental Models to Define the Genetic Predisposition to Liver Cancer
por: Pascale, Rosa M., et al.
Publicado: (2019)

Methylation analysis of the phosphates and tensin homologue on chromosome 10 gene (PTEN) in multiple myeloma
por: Piras, Giovanna, et al.
Publicado: (2014)

Pathogenetic and Prognostic Significance of Inactivation of RASSF Proteins in Human Hepatocellular Carcinoma
por: Calvisi, Diego F., et al.
Publicado: (2012)

CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype
por: Mancarella, Serena, et al.
Publicado: (2022)

Correction: CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype
por: Mancarella, Serena, et al.
Publicado: (2023)

eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma
por: Steinmann, Sara M., et al.
Publicado: (2023)

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade
por: Jia, Jiaoyuan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_91pcu1r0g04nmmavd1najd0qmc