Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound

Despite intensive efforts in the search for small molecules with anti-cancer activity, it remains challenging to achieve both high effectiveness and safety, since many agents lack the selectivity to only act on cancer cells. The interface of two apoptotic proteins, myeloid cell leukemia-1 (Mcl-1) an...

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Detalles Bibliográficos
Autores principales: Liu, Jiyuan, Tian, Zhen, Zhou, Nan, Liu, Xueying, Liao, Chenyi, Lei, Beilei, Li, Jianing, Zhang, Shengyong, Chen, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589576/
https://www.ncbi.nlm.nih.gov/pubmed/28903337
http://dx.doi.org/10.18632/oncotarget.17294

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