Preoperative transcatheter arterial chemotherapy may suppress oxidative stress in hepatocellular carcinoma cells and reduce the risk of short-term relapse

In this study, we aim to investigate oxidative stress in hepatocellular carcinoma (HCC) tissues in patients receiving preoperative transcatheter arterial chemotherapy (TAC) and its association with prognosis. A total of 89 HCC patients enrolled in this study, 39 received preoperative TAC 1 week befo...

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Detalles Bibliográficos
Autores principales: Su, Hao, Zhu, Guangzhi, Djaja P, Ketut Indra, Lin, Yi, Gong, Yizhen, Liu, Xiaoguang, Li, Jiaquan, Liu, Zhiming, Qin, Xiao, Li, Lequn, Liu, Tangwei, Lu, Zili, Wei, Minyi, Yan, Lunan, Winkler, Cheryl Ann, O’Brien, Stephen J., Li, Jing, Xiao, Kaiyin, Peng, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589590/
https://www.ncbi.nlm.nih.gov/pubmed/28903351
http://dx.doi.org/10.18632/oncotarget.17660
Descripción
Sumario:In this study, we aim to investigate oxidative stress in hepatocellular carcinoma (HCC) tissues in patients receiving preoperative transcatheter arterial chemotherapy (TAC) and its association with prognosis. A total of 89 HCC patients enrolled in this study, 39 received preoperative TAC 1 week before surgery (pTAC group) and 50 did not (non-pTAC group). All patients underwent hepatectomy and postoperative TAC and were followed up to 400 weeks. Samples of liver tissue without HCC and hepatitis (n = 15) served as normal controls. Cellular levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), TP53, and p21(waf1/cip1) were measured in both cancer and surrounding tissues using an immunohistochemistry assay. Taken together, our data suggested that preoperative TAC might postpone postoperative HCC relapse within 1 year via suppression of tumor cells by induction of high levels of oxidative stress.

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