HER2 isoforms co-expression differently tunes mammary tumor phenotypes affecting onset, vasculature and therapeutic response

Full-length HER2 oncoprotein and splice variant Delta16 are co-expressed in human breast cancer. We studied their interaction in hybrid transgenic mice bearing human full-length HER2 and Delta16 (F1 HER2/Delta16) in comparison to parental HER2 and Delta16 transgenic mice. Mammary carcinomas onset wa...

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Detalles Bibliográficos
Autores principales: Palladini, Arianna, Nicoletti, Giordano, Lamolinara, Alessia, Dall’Ora, Massimiliano, Balboni, Tania, Ianzano, Marianna L., Laranga, Roberta, Landuzzi, Lorena, Giusti, Veronica, Ceccarelli, Claudio, Santini, Donatella, Taffurelli, Mario, Di Oto, Enrico, Asioli, Sofia, Amici, Augusto, Pupa, Serenella M., De Giovanni, Carla, Tagliabue, Elda, Iezzi, Manuela, Nanni, Patrizia, Lollini, Pier-Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589593/
https://www.ncbi.nlm.nih.gov/pubmed/28903354
http://dx.doi.org/10.18632/oncotarget.17088

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